ORPHA:2902
Idiopathic chronic eosinophilic pneumonia
Also known as: Chronic eosinophilic pneumonia
Publications
1,271
Trials
1
Interventional, condition-specific
Researchers
1,132
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
A rare, severe, interstitial lung disease characterized by insidious onset with subacute or chronic non-specific respiratory manifestations (dyspnea, cough, wheezing) often associated with systemic manifestations (fatigue, malaise, weight loss) and a history of asthma (up to half of patients). Eosinophilia is present in most cases, usually in excess of 1000 cells/mm3.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017363
- MeSH:C535590
- UMLS:C2930941
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,271 matched papers (626 in last 10 years) Source
- Phenotype characterisedPresent
27 HPO annotations (e.g. Increased circulating IgE concentration; Elevated erythrocyte sedimentation rate; Hypersensitivity pneumonitis) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
1 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
27
Associated phenotypes · MONDO:0017363
- Increased circulating IgE concentration
- Elevated erythrocyte sedimentation rate
- Hypersensitivity pneumonitis
- Elevated circulating C-reactive protein concentration
- Nonproductive cough
Showing 5 of 27 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
1,271
1,271 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
1,271 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
626 in the last 10 years · low confidence
Phrase hits: 1,271 · MeSH hits: 0
Who's working on it?
1,132
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01
- 02Hatsukawa H4 papers · 2026
Department of Otolaryngology, Head and Neck Surgery Hyogo Prefectural Amagasaki General Medical Center Amagasaki Japan.
Papers in Europe PMC - 03Hirai T4 papers · 2025
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Japan.
Papers in Europe PMC - 04Ishikawa M4 papers · 2026
Department of Otolaryngology, Head and Neck Surgery Hyogo Prefectural Amagasaki General Medical Center Amagasaki Japan.
Papers in Europe PMC - 05Matsumoto H4 papers · 2025
Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Kanazawa-ku, Japan.
Papers in Europe PMC - 06Caminati M3 papers · 2026
Department of Medicine, University of Verona & AOUI Verona, Policlinico GB Rossi, Piazzale L.A. Scuro, 10, 37134, Verona, Italy. marco.caminati@univr.it.
Papers in Europe PMC - 07Chen X3 papers · 2025
Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Papers in Europe PMC - 08Daboussi S3 papers · 2023
Department of Respiratory Medicine, Military Hospital of Instruction of Tunis, Tunis, Tunisia.
Papers in Europe PMC - 09Endo K3 papers · 2025
Department of Respiratory Medicine Hyogo Prefectural Amagasaki General Medical Center Amagasaki Japan.
Papers in Europe PMC - 10Jiang Z3 papers · 2026
Bioinformatics Center, Institute For Chemical Research, Kyoto University, Uji, Kyoto, Japan.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
1
interventional trials for this specific condition
1 interventional trial matched this specific condition name; none in our sample are currently recruiting.
Data as of 11 September 2026
1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).
low confidence · 80.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
1 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Broader category: eosinophilic pneumonia
0
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Parent-category matching found a broader label but no interventional trials under it. How we count trials.
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 3 · after dedupe 3 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 3 · dropped 0 · fetched 2026-07-29
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (3)
- isrctn·ISRCTN17701271·Not yet recruiting·129Xenon MRI study of the effects of Mepolizumab on inflammation in the lungs of patients with chronic obstructive pulmonary disease (COPD)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN85620156·Suspended·A controlled clinical trial to evaluate a personalised treatment approach for the management of acute exacerbations (flare-ups) of chronic obstructive pulmonary disease (COPD)
skipped — LLM skipped (--skip-llm)
- isrctn·ISRCTN90445176·No longer recruiting·STudying Acute exaceRbations and Responses: COPD STARR Study. v1.0
skipped — LLM skipped (--skip-llm)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Idiopathic chronic eosinophilic pneumonia — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Idiopathic chronic eosinophilic pneumonia" OR "Chronic eosinophilic pneumonia"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Idiopathic chronic eosinophilic pneumonia" OR "Chronic eosinophilic pneumonia"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"eosinophilic pneumonia"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (1271) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-26T21:37:15.474Z