ORPHA:289385
Malignancy diagnosed during pregnancy
Also known as: Cancer diagnosed during pregnancy
Publications
518
86.5th percentile
Trials
0
Interventional, condition-specific
Researchers
1,343
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A rare condition characterized by the occurrence and/or diagnosis of a malignancy during pregnancy. The most frequently diagnosed neoplasms are gynecologic tumors, especially cervical cancer, followed by hematologic malignancies. Patient management should be carried out by a multidisciplinary team of specialists.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017330
- UMLS:C5679948
Additional Mondo synonyms (1)
cancer diagnosed during pregnancy
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
518 matched papers (346 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
518
518 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
518 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
346 in the last 10 years · high confidence · 86.5th percentile (publications denominator)
Phrase hits: 518 · MeSH hits: 0
Who's working on it?
1,343
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Bakhuis CFJ6 papers · 2026
Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Papers in Europe PMC - 02Johansson ALV6 papers · 2026
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. anna.johansson@ki.se.
Papers in Europe PMC - 03van der Wall E6 papers · 2026
Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Papers in Europe PMC - 04van Diest PJ6 papers · 2026
Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
Papers in Europe PMC - 05van Dooijeweert C6 papers · 2026
Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: c.vandooijeweert-3@umcutrecht.nl.
Papers in Europe PMC - 06Amant F5 papers · 2026
Unit of Gynecological Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Papers in Europe PMC - 07Saura C5 papers · 2025
Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus. Barcelona, Spain.
Papers in Europe PMC - 08Suelmann BBM5 papers · 2026
Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Papers in Europe PMC - 09Cardonick E4 papers · 2026
Department of Obstetrics and Gynecology, Cooper University Health Care, Camden, New Jersey, USA.
Papers in Europe PMC - 10Fredriksson I4 papers · 2026
Department of Breast, Endocrine Tumors and Sarcoma, D2:02, Karolinska University Hospital, Stockholm, SE-16757, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address: irma.fredriksson@sll.se.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 3 observational studies did — shown below because natural-history and cohort work can be an important step toward a trial.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Observational and natural-history studies
3 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT03598361·RECRUITING·Mineral Status in Pregnant Women
Conditions: Pregnancy; Disorder, Blood·Matched via recall expansion
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Malignancy diagnosed during pregnancy" OR "Cancer diagnosed during pregnancy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Malignancy diagnosed during pregnancy" OR "Cancer diagnosed during pregnancy" OR "pregnancy disorder"
Recall-expansion terms: pregnancy disorder
Study-type breakdown: 0 interventional · 3 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, recall-expansion; with hits: phrase, recall-expansion
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T12:13:00.481Z