ORPHA:289347
Infective dermatitis associated with HTLV-1
Also known as: IDH · Infective dermatitis associated with human T-lymphotropic virus type 1 · Infective dermatitis associated with human T-lymphotropic virus type I
Publications
96
59.8th percentile
Trials
0
Interventional, condition-specific
Researchers
592
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Infective dermatitis associated with HTLV-1 is a rare and severe chronic disease characterized by recurrent chronic eczema (with erythematous, scaly and crusted lesions) mainly affecting seborrheic areas (e.g. scalp, forehead, eyelids, paranasal and periauricular skin, neck, axillae, and groin), a generalized fine papular rash, chronic nasal discharge with crusting of the anterior nares, and non-virulent Staphylococcus aureus or beta-hemolytic Streptococcus infections, thought to be a result of HTLV-1-induced immunosuppression. Lymphadenopathy, anemia, mild to moderate pruritus and increased incidence of other infections (e.g. crusted scabies) have also been reported in some patients. Patients may subsequently develop other HTLV-1 associated conditions such as adult T-cell leukemia/lymphoma and tropical spastic paraparesis.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017326
- UMLS:C4274291
- NCIT:C129260
Additional Mondo synonyms (4)
IDH Gene family · infective dermatitis associated with human T-lymphotropic virus type 1 · infective dermatitis associated with human T-lymphotropic virus type I · isocitrate dehydrogenase Gene family
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
96 matched papers (69 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
96
96 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
96 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
69 in the last 10 years · medium confidence · 59.8th percentile (publications denominator)
Phrase hits: 96 · MeSH hits: 0
Who's working on it?
592
Distinct author names in 96 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Bittencourt AL13 papers · 2024
Laboratory of Pathology, Complexo Hospitalar Universitário Prof. Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil. achilea@uol.com.br
Papers in Europe PMC - 02Farre L12 papers · 2024
1Laboratory of Experimental Pathology, CPQGM, FIOCRUZ, Salvador, Bahia, 40296710, Brazil
Papers in Europe PMC - 03Bittencourt A7 papers · 2017
Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
Papers in Europe PMC - 04Carvalho EM6 papers · 2020
Fundação Oswaldo Cruz, Brazil; Universidade Federal da Bahia, Brazil.
Papers in Europe PMC - 05Gotuzzo E5 papers · 2026
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Papers in Europe PMC - 06Oliveira PD5 papers · 2022
Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil. Electronic address: pedrodermato@yahoo.com.br.
Papers in Europe PMC - 07Hlela C4 papers · 2025
Department of Immunology, Wright-Fleming Institute, Imperial College London, London, W2 1PG, UK
Papers in Europe PMC - 08Primo J4 papers · 2019
Departamento de Medicina Interna, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brasil.
Papers in Europe PMC - 09Wang Y4 papers · 2024
Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Papers in Europe PMC - 10Clark D3 papers · 2013
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Infective dermatitis associated with HTLV-1" OR "Infective dermatitis associated with human T-lymphotropic virus type 1" OR "Infective dermatitis associated with human T-lymphotropic virus type I" OR "IDH Gene family" OR "isocitrate dehydrogenase Gene family"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Infective dermatitis associated with HTLV-1" OR "Infective dermatitis associated with human T-lymphotropic virus type 1" OR "Infective dermatitis associated with human T-lymphotropic virus type I" OR "IDH Gene family" OR "isocitrate dehydrogenase Gene family"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: IDH
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T12:11:50.487Z