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ORPHA:279914

Intermediate uveitis

low confidenceDisorder

Also known as: IU

Publications

2,795

Trials

27

Interventional, condition-specific

Researchers

1,022

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare ophthalmic disorder characterized by intraocular inflammation primarily localized to the vitreous and peripheral retina. It incorporates pars planitis, posterior cyclitis, and hyalitis. Patients present with painless floaters, decreased or blurred vision, less frequently with pain, redness, and photophobia. On examination, snow banking, vitreous snowballs, peripheral retinal vascular sheathing, vitreous cells, and vitreous haze can be seen. Complications include epiretinal membrane formation, cataract formation, cystoid macular edema, or band keratopathy, among others. The condition may be or occur in the context of infectious or systemic diseases.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

intermediate uveitis · intermediate uveitis (disease)

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    2,795 matched papers (1,777 in last 10 years) Source

  3. Phenotype characterisedPresent

    18 HPO annotations (e.g. Psoriasiform dermatitis; Chronic infection; Macular scar) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPresent

    1 FDA designation (1 FDA orphan-indication approval) — e.g. sirolimus Source

  6. Interventional trialPresent

    27 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

18

Associated phenotypes · MONDO:0006806

  • Psoriasiform dermatitis
  • Chronic infection
  • Macular scar
  • Vitreous floaters
  • Tubulointerstitial nephritis

Showing 5 of 18 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · 1 with FDA orphan-indication approval

  • FDA sirolimusInfectious Uveitis Intermediate uveitis Anterior Posterior Noninfectious panuveitis · 2011-11-04 · Not FDA Approved for Orphan Indication

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

10

Drugs / clinical candidates · MONDO_0006806

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

2,795

2,795 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

2,795 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

1,777 in the last 10 years · low confidence

Phrase hits: 2,793 · MeSH hits: 16

Open Europe PMC search

Who's working on it?

1,022

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Biswas J9 papers · 2026

    Department of Uvea and Intraocular Inflammation, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

    Papers in Europe PMC
  2. 02
    de-la-Torre A5 papers · 2026

    Ophthalmology Interest Group-Universidad del Rosario (OIG UR), Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

    Papers in Europe PMC
  3. 03
    Dutta Majumder P5 papers · 2026

    Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, 18, College Road, Chennai, Tamil Nadu, India.

    Papers in Europe PMC
  4. 04
    Yeh S5 papers · 2026

    Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska.

    Papers in Europe PMC
  5. 05
    Finger RP4 papers · 2026

    Department of Ophthalmology, University Hospital Bonn, Venusberg-Campus 1, Ernst-Abbe-Straße 2, 53127, Bonn, Germany.

    Papers in Europe PMC
  6. 06
    Subhi Y4 papers · 2026

    Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

    Papers in Europe PMC
  7. 07
    Abdullatif AM3 papers · 2026

    Department of Ophthalmology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.

    Papers in Europe PMC
  8. 08
    Agrawal R3 papers · 2026

    Department of Ophthalmology, Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore, Singapore.

    Papers in Europe PMC
  9. 09
    Amer R3 papers · 2025

    Hadassah Medical Center, Department of Ophthalmology, Jerusalem, Israel.

    Papers in Europe PMC
  10. 10
    Amin RH3 papers · 2026

    Department of Ophthalmology, Kasr AlAiny Hospital, Cairo University, Cairo, Egypt.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

27

interventional trials for this specific condition

27 interventional trials matched this specific condition name; 1 currently recruiting in our sample. 200 trials are registered for uveitis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

27 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 95.7th percentile).

low confidence · 95.7th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

27 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: uveitis

200

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

4 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 8 · after dedupe 8 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 8 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (8)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Intermediate uveitis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Intermediate uveitis" OR "intermediate uveitis (disease)"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Uveitis, Intermediate

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Intermediate uveitis" OR "intermediate uveitis (disease)" OR "Uveitis, Intermediate"

Interventional trials matched via: both, phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 27 interventional · 4 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"uveitis"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: IU

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (2795) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T11:44:42.161Z