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ORPHA:276429

Hypnic headache

high confidenceDisorder

Publications

354

62.6th percentile

Trials

12

Interventional, condition-specific

Researchers

751

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare headache characterized by recurrent brief, intense headache attacks occurring exclusively during sleep, typically at the same time of the night, causing the patient to wake up. The pain usually lasts more than 15 minutes after waking. It is mostly bilateral and may be associated with nausea, photophobia, or phonophobia, while characteristically no autonomic symptoms are present.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (2)

hypnic headache · hypnic headache (disease)

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    354 matched papers (143 in last 10 years) Source

  3. Phenotype characterisedPresent

    162 HPO annotations (e.g. Migraine; Miosis; Diabetes mellitus) Source

  4. Animal modelPresent

    8 genotype models (Mus musculus) Source

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    12 matched on ClinicalTrials.gov (4 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

162

Associated phenotypes · MONDO:0017181

  • Migraine
  • Miosis
  • Diabetes mellitus
  • Hypertension
  • Neck pain

Showing 5 of 162 — open Monarch for the full list.

Animal models (Monarch / Alliance)

8

Model associations linked to this Mondo ID

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

11 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Acetazolamide · therapeutic
  • Amitriptyline · therapeutic
  • Enalapril · therapeutic
  • Lithium Carbonate · therapeutic
  • Metoclopramide · therapeutic
  • Ergotamine · marker/mechanism
  • Excitatory Amino Acid Agonists · marker/mechanism
  • Nitric Oxide · marker/mechanism
  • Nitroglycerin · marker/mechanism
  • Norepinephrine · marker/mechanism
  • Serotonin · marker/mechanism

MyDisease.info · MONDO:0017181

Literature

Is anyone studying this?

354

354 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

354 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

143 in the last 10 years · high confidence · 62.6th percentile (publications denominator)

Phrase hits: 340 · MeSH hits: 15

Open Europe PMC search

Who's working on it?

751

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Holle D11 papers · 2025

    Department of Neurology, West German Headache and Vertigo Center, Essen University Hospital (AöR), Essen, Germany.

    Papers in Europe PMC
  2. 02
    Obermann M11 papers · 2025

    Department of Neurology, Klinikum Weser-Egge, Höxter, Germany.

    Papers in Europe PMC
  3. 03
    Diener HC8 papers · 2017

    Department of Neurology, University Hospital Essen, University Duisburg-Essen, Essen, Germany. hans.diener@uk-essen.de.

    Papers in Europe PMC
  4. 04
    Goadsby PJ8 papers · 2025

    NIHR King's Clinical Research Facility, King's College, London, UK.

    Papers in Europe PMC
  5. 05
    Naegel S7 papers · 2017

    Department of Neurology and Westgerman Headache Center Essen, University Duisburg-Essen, Germany.

    Papers in Europe PMC
  6. 06
    Gaul C6 papers · 2022

    Department of Neurology and Headache Center, University of Duisburg-Essen, Essen, Germany.

    Papers in Europe PMC
  7. 07
    Pascual J6 papers · 2021

    Service of Neurology, University Hospital Marqués de Valdecilla, 39008 Santander, Spain. juliopascual@telefonica.net

    Papers in Europe PMC
  8. 08
    Silva-Néto RP5 papers · 2019

    Center of Neurology and Headache of Piauí, 54001-260 Teresina, Brazil.

    Papers in Europe PMC
  9. 09
    Zhang P5 papers · 2026

    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

    Papers in Europe PMC
  10. 10
    Katsarava Z4 papers · 2011
    Papers in Europe PMC

Clinical research

Is a treatment being tested?

12

interventional trials for this specific condition

12 interventional trials matched this specific condition name; 4 currently recruiting in our sample.

Data as of 11 September 2026

12 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 93.2th percentile).

high confidence · 93.2th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

12 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

11 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 1 · after dedupe 1 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 1 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (1)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Hypnic headache — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Hypnic headache" OR "hypnic headache (disease)"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Headache Disorders, Primary

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Hypnic headache" OR "hypnic headache (disease)" OR "Headache Disorders, Primary"

Interventional trials matched via: mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 12 interventional · 11 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T11:42:06.849Z