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ORPHA:26790

Pseudomyxoma peritonei

low confidenceDisorder

Also known as: Adenomucinosis · Gelatinous ascites · PMP

Publications

19,532

Trials

25

Interventional, condition-specific

Researchers

1,043

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

Pseudomyxoma peritonei is characterized by disseminated intra-peritoneal mucinous tumors and mucinous ascites in the abdomen and pelvis.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (7)

Myxoma peritonei · gelatinous ascites · mucinous ascites · peritoneal cavity pseudomyxoma peritonei · pseudomyxoma peritonei · pseudomyxoma peritonei (morphologic abnormality) · well differentiated peritoneal mucinous adenocarcinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    19,532 matched papers (11,953 in last 10 years) Source

  3. Phenotype characterisedPresent

    12 HPO annotations (e.g. Inflammation of the large intestine; Intestinal obstruction; Weight loss) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPartial

    2 EMA designations (none yet with FDA orphan-indication approval) — e.g. bromelain Source

  6. Interventional trialPresent

    25 matched on ClinicalTrials.gov (9 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

12

Associated phenotypes · MONDO:0017048

  • Inflammation of the large intestine
  • Intestinal obstruction
  • Weight loss
  • Nausea and vomiting
  • Constipation

Showing 5 of 12 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

2

Designations · no FDA orphan-indication approval yet

  • EMA bromelainTreatment of pseudomyxoma peritonei · 14/12/2018 · PositiveEMA designation
  • EMA acetylcysteineTreatment of pseudomyxoma peritonei · 14/12/2018 · PositiveEMA designation

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

19,532

19,532 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

19,532 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

11,953 in the last 10 years · low confidence

Phrase hits: 19,532 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,043

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Ma R12 papers · 2026

    Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, China; Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China. Electronic address: maruiqing2014@126.com.

    Papers in Europe PMC
  2. 02
    Li Y10 papers · 2026

    Department of Urology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

    Papers in Europe PMC
  3. 03
    Zhang P7 papers · 2026

    Department of Breast Surgery, Jilin Cancer Hospital, Changchun, Jilin, China.

    Papers in Europe PMC
  4. 04
    Shi G6 papers · 2026

    Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China.

    Papers in Europe PMC
  5. 05
    Wang C6 papers · 2026

    Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China.

    Papers in Europe PMC
  6. 06
    An L5 papers · 2026

    Department of Myxoma, Aerospace Center Hospital, Beijing, 100049, China.

    Papers in Europe PMC
  7. 07
    Abatini C4 papers · 2026

    Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. carlo.abatini@policlinicogemelli.it.

    Papers in Europe PMC
  8. 08
    Barberis L4 papers · 2026

    General Surgery Department, Università Cattolica del Sacro Cuore, Rome, Italy.

    Papers in Europe PMC
  9. 09
    Calegari MA4 papers · 2026

    Comprehensive Cancer Center, Division of Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

    Papers in Europe PMC
  10. 10
    D'Annibale G4 papers · 2026

    General Surgery Department, Università Cattolica del Sacro Cuore, Rome, Italy.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

25

interventional trials for this specific condition

25 interventional trials matched this specific condition name; 9 currently recruiting in our sample.

Data as of 11 September 2026

25 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 95.5th percentile).

low confidence · 95.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

25 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

9 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 5 · after dedupe 5 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 5 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (5)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Pseudomyxoma peritonei — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Pseudomyxoma peritonei" OR "Adenomucinosis" OR "Gelatinous ascites" OR "Myxoma peritonei" OR "mucinous ascites" OR "peritoneal cavity pseudomyxoma peritonei" OR "pseudomyxoma peritonei (morphologic abnormality)" OR "well differentiated peritoneal mucinous adenocarcinoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Pseudomyxoma peritonei" OR "Adenomucinosis" OR "Gelatinous ascites" OR "Myxoma peritonei" OR "mucinous ascites" OR "peritoneal cavity pseudomyxoma peritonei" OR "pseudomyxoma peritonei (morphologic abnormality)" OR "well differentiated peritoneal mucinous adenocarcinoma"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 25 interventional · 9 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: PMP

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (19532) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T23:21:20.655Z