ORPHA:264978
Drug or radiation exposure-related interstitial lung disease
Publications
0
Trials
0
Interventional, condition-specific
Researchers
0
Distinct authors in sample
Gene link
—
Readiness
0/6
Stages with a signal
Clinical definition (Orphanet)
A rare secondary interstitial lung disease (ILD) characterized by development of the condition after exposure to certain drugs or radiation therapy. Diagnostic criteria include clear temporal association, identification of a characteristic reaction pattern to the respective drug, and exclusion of other causes of the ILD. Clinically, drug-induced ILD (DI-ILD) may occur as acute ILD with respiratory failure, or as subacute/chronic DI-ILD. Radiation injury to the lung can develop during or following radiation therapy and depends on the nature and dose of the ionizing radiation, as well as the direction of the radiation beam.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0017039
- UMLS:C5680746
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
0/6 stages with a signal
Search queries returned nothing — this usually means a naming mismatch, not proof that nothing exists.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteratureNot checked
Query returned nothing — not evidence of absence Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot checked
Broken query — trial zero not trusted
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
0
We found no papers under this exact name — work may still exist under another label.
0 in the last 10 years · low confidence
Phrase hits: 0 · MeSH hits: 0
Who's working on it?
0
Distinct author names in 0 sampled papers.
Who's working on it?
No author names could be extracted from the sampled publications. Try the Europe PMC query in “How we counted this,” or contact an umbrella rare-disease organisation for researcher referrals.
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 295 trials are registered for interstitial lung disease, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
295 interventional trials matched interstitial lung disease, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: interstitial lung disease
295
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT01280994·RECRUITING·Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
Conditions: Interstitial Lung Disease·Matched via name phrase
- NCT07643038·NOT YET RECRUITING·Treatment Strategy for Patients With RA-ILD
Conditions: Rheumatoid Arthritis Associated Interstitial Lung Disease·Matched via name phrase
- NCT07473700·NOT YET RECRUITING·Study of TX000045 in Participants With Pulmonary Hypertension Due to Interstitial Lung Disease
Conditions: Hypertension, Pulmonary · Lung Diseases, Interstitial·Matched via name phrase
- NCT06767904·NOT YET RECRUITING·Continuous Versus Demand-Based Oxygen in Patients With Fibrotic Interstitial Lung Disease and Chronic Obstructive Pulmonary Disease
Conditions: Interstitial Lung Disease · Chronic Obstructive Pulmonary Disease·Matched via name phrase
- NCT07319598·RECRUITING·A Study to Test Tetrandrine Tablets for Connective Tissue Disease-Related Lung Disease
Conditions: Interstitial Lung Disease (ILD) · Connective Tissue Disease-associated Interstitial Lung Disease·Matched via name phrase
- NCT06297096·RECRUITING·Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and Interstitial Lung Disease
Conditions: Systemic Sclerosis · Interstitial Lung Disease·Matched via name phrase
- NCT06326957·RECRUITING·Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
Conditions: Chronic Obstructive Pulmonary Disease · Bronchiectasis · Interstitial Lung Disease · Lung Cancer·Matched via name phrase
- NCT03630211·RECRUITING·Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
Conditions: Systemic Sclerosis · Diffuse Sclerosis Systemic · Interstitial Lung Disease · Pulmonary Hypertension·Matched via name phrase
- NCT06247397·RECRUITING·Effect of HIgh-flow Therapy in Long-term Oxygen Therapy
Conditions: Chronic Obstructive Pulmonary Disease Severe · Interstitial Lung Disease · Chronic Respiratory Failure With Hypoxia·Matched via name phrase
- NCT07141810·NOT YET RECRUITING·Efficacy and Safety of Early Antifibrotic Therapy for Non-progressive Fibrotic Interstitial Lung Disease
Conditions: Fibrotic Interstitial Lung Disease·Matched via name phrase
- NCT06911632·RECRUITING·Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Conditions: Pulmonary Hypertension · Interstitial Lung Disease (ILD)·Matched via name phrase
- NCT06992661·RECRUITING·A Study of the Pharmacokinetics and Safety of Single-dose Inhaled RJ026 in Healthy Volunteers and Patients With Interstitial Lung Disease
Conditions: Interstitial Lung Disease (ILD) · Healthy Volunteers·Matched via name phrase
- NCT07539701·NOT YET RECRUITING·An Initial Experience With the Disposable Celsio Cryocatheter System for Diagnostic and Interventional Bronchoscopy
Conditions: Lung Cancer (Diagnosis) · Interstitial Lung Disease (ILD)·Matched via name phrase
- NCT07283081·RECRUITING·Impact of Capillaroscopy in the Investigation of Diffuse Interstitial Pneumonias
Conditions: Interstitial Lung Disease · Connective Tissue Diseases·Matched via name phrase
- NCT07451977·RECRUITING·Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia
Conditions: Chronic Respiratory Failure · Hypoxemia · Chronic Obstructive Pulmonary Disease (COPD) · Interstitial Lung Disease·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Drug or radiation exposure-related interstitial lung disease"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Drug or radiation exposure-related interstitial lung disease"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"interstitial lung disease"
Query health: broken — strategies attempted: phrase; with hits: none
Parent literature probe: interstitial lung disease (MONDO:0015925) — 58676 hits
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Zero publications but parent term interstitial lung disease has 58676 — literature likely indexed under a broader name
Ingested 2026-07-27T11:26:12.981Z · excluded from neglect metrics