ORPHA:2583
Mycetoma
Also known as: Madura foot
Publications
6,455
Trials
2
Interventional, condition-specific
Researchers
936
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A neglected tropical infection, rare in Europe, characterized by subcutaneous tumorous lesions in which mycetoma grains containing the causative agent can be observed. Mycetoma is a broad term encompassing both actinomycetoma (bacterial) and eumycetoma (fungal).
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0016823
- MeSH:D008271
- UMLS:C0024449
- NCIT:C85505
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
6,455 matched papers (2,420 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
2 matched on ClinicalTrials.gov (1 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
6,455
6,455 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
6,455 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
2,420 in the last 10 years · low confidence
Phrase hits: 6,455 · MeSH hits: 0
Who's working on it?
936
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Fahal AH16 papers · 2026
Mycetoma Research Center, Soba University Hospital, University of Khartoum, Khartoum, Sudan.
Papers in Europe PMC - 02Saeed AA12 papers · 2026
Mycetoma Research Center, Soba University Hospital, University of Khartoum, Khartoum, Sudan.
Papers in Europe PMC - 03van de Sande WWJ10 papers · 2026
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The, Netherlands.
Papers in Europe PMC - 04Fahal A8 papers · 2026
The Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.
Papers in Europe PMC - 05Siddig EE7 papers · 2026
Department of Medical Microbiology and Infectious Diseases Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands.
Papers in Europe PMC - 06Smith DJ6 papers · 2026
Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, USA.
Papers in Europe PMC - 07Ahmed A5 papers · 2025
Institute of Endemic Diseases University of Khartoum Khartoum Sudan.
Papers in Europe PMC - 08Gupta S4 papers · 2026
Department of Dermatology, Dr D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, India.
Papers in Europe PMC - 09
- 10Hussein SME4 papers · 2026
Mycetoma Research Center, Soba University Hospital, University of Khartoum, Khartoum, Sudan.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
2
interventional trials for this specific condition
2 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 27 July 2026
2 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 82.4th percentile).
low confidence · 82.4th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
2 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07506967·NOT YET RECRUITING·Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Conditions: Skin and Connective Tissue Diseases · Neglected Tropical Diseases · Leprosy · Buruli Ulcer·Matched via name phrase
Observational and natural-history studies
3 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06512714·RECRUITING·Mycetoma Retrospective Data Collection
Conditions: Mycetoma·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Mycetoma" OR "Madura foot"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Mycetoma" OR "Madura foot"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 2 interventional · 3 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is short or not clearly distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (6455) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-26T20:35:57.573Z