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ORPHA:254693

Partial hydatidiform mole

low confidenceSubtype of disorder

Also known as: Incomplete hydatidiform mole · Incomplete molar pregnancy · Partial molar pregnancy

Publications

1,583

Trials

1

Interventional, condition-specific

Researchers

1,040

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A form of hydatiform mole characterized by abnormal hyperplastic trophoblasts and hydropic villi due to fertilization of a normal ovocyte by two spermatozoa or one abnormal spermatozoon (allowing for some fetal development), and that manifests with vaginal bleeding accompanied by nausea and frequent vomiting, hyperemesis gravidarum, hyperthyroidism and risk of spontaneous miscarriage.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (6)

incomplete hydatid Mole · incomplete hydatidiform mole · incomplete molar pregnancy · partial Mole · partial hydatid Mole · partial molar pregnancy

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,583 matched papers (663 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

1,583

1,583 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

1,583 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

663 in the last 10 years · low confidence

Phrase hits: 1,583 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,040

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Braga A9 papers · 2026

    Department of Obstetrics and Gynecology, Maternity School of Rio de Janeiro Federal University; Department of Maternal Child, Antonio Pedro University Hospital of Fluminense Federal University, Rio de Janeiro Trophoblastic Disease Center (Drs. Braga and Padrón), Rio de Janeiro, Brazil; Postgraduate Program in Perinatal Health, Faculty of Medicine, Maternity School of Rio de Janeiro Federal University (Dr. Braga), Rio de Janeiro, Brazil; Postgraduate Program in Medical Sciences, Fluminense Federal University, Niterói (Dr. Braga), Rio de Janeiro, Brazil. Electronic address: antonio.braga@ufrj.br.

    Papers in Europe PMC
  2. 02
    Berkowitz RS5 papers · 2026

    New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs. Elias, Horowitz, and Berkowitz).

    Papers in Europe PMC
  3. 03
    Cai L5 papers · 2026

    Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, PR China.

    Papers in Europe PMC
  4. 04
    Gergely L5 papers · 2026

    Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University Bratislava, Bratislava, Slovak Republic.

    Papers in Europe PMC
  5. 05
    Araujo Júnior E4 papers · 2026

    Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), Sao Paulo 04023-062, SP, Brazil.

    Papers in Europe PMC
  6. 06
    Horowitz NS4 papers · 2026

    New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Drs. Elias, Horowitz, and Berkowitz).

    Papers in Europe PMC
  7. 07
    McCullough L4 papers · 2026

    Centre for Gestational Trophoblastic Disease of Slovak Republic , ,

    Papers in Europe PMC
  8. 08
    Nisa AS4 papers · 2026

    Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.

    Papers in Europe PMC
  9. 09
    Sun SY4 papers · 2026

    Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), Sao Paulo 04023-062, SP, Brazil.

    Papers in Europe PMC
  10. 10
    Zhao Y4 papers · 2026

    Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou City, Zhejiang Province, PR China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting. 6 trials are registered for hydatidiform mole, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).

low confidence · 76.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: hydatidiform mole

6

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Partial hydatidiform mole" OR "Incomplete hydatidiform mole" OR "Incomplete molar pregnancy" OR "Partial molar pregnancy" OR "incomplete hydatid Mole" OR "partial Mole" OR "partial hydatid Mole"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Partial hydatidiform mole" OR "Incomplete hydatidiform mole" OR "Incomplete molar pregnancy" OR "Partial molar pregnancy" OR "incomplete hydatid Mole" OR "partial Mole" OR "partial hydatid Mole"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"hydatidiform mole"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1583) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T11:05:51.515Z