ORPHA:252018
Teratoma of the central nervous system
Publications
58
45.3th percentile
Trials
6
Interventional, condition-specific
Researchers
375
Distinct authors in sample
Gene link
—
Readiness
3/6
Stages with a signal
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0002718
- UMLS:C1332895
- NCIT:C5441
Additional Mondo synonyms (6)
CNS teratoma · central nervous system teratoma · teratoma of CNS · teratoma of central nervous system · teratoma of the CNS · teratoma of the central nervous system
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
58 matched papers (41 in last 10 years) Source
- Phenotype characterisedPresent
8 HPO annotations (e.g. Abnormal abdomen morphology; Diplopia; Nystagmus) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialPresent
6 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
8
Associated phenotypes · MONDO:0002718
- Abnormal abdomen morphology
- Diplopia
- Nystagmus
- Polydipsia
- Teratoma
Showing 5 of 8 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
58
58 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
58 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
41 in the last 10 years · high confidence · 45.3th percentile (publications denominator)
Phrase hits: 58 · MeSH hits: 0
Who's working on it?
375
Distinct author names in 58 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Brito VN2 papers · 2023
Discipline of Endocrinology & Metabolism, Department of Internal Medicine, University of Sao Paulo Medical School, University of Sao Paulo, Sao Paulo 01246 903, Brazil.
Papers in Europe PMC - 02Kim SK2 papers · 2014
Division of Pediatric Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Papers in Europe PMC - 03Lehrnbecher T2 papers · 2021
Division of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Papers in Europe PMC - 04Liu L2 papers · 2024
Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China.
Papers in Europe PMC - 05Mirchia K2 papers · 2022
Department of Radiology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA.
Papers in Europe PMC - 06Park SH2 papers · 2014
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. ; Neuroscience Institute, Seoul National University College of Medicine, Seoul, Korea.
Papers in Europe PMC - 07A'Hern RP1 paper · 1990Papers in Europe PMC
- 08Abdali H1 paper · 2021
Department of Surgery, School of Medicine, Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Papers in Europe PMC - 09Abramov I1 paper · 2025
The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States.
Papers in Europe PMC - 10Abramowsky CR1 paper · 2007Papers in Europe PMC
Clinical research
Is a treatment being tested?
6
interventional trials for this specific condition
6 interventional trials matched this specific condition name; none in our sample are currently recruiting. 21 trials are registered for teratoma, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 11 September 2026
6 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 90.1th percentile).
high confidence · 90.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
6 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Broader category: teratoma
21
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT04684368·RECRUITING·A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Not reviewed·Conditions: Central Nervous System Nongerminomatous Germ Cell Tumor · Choriocarcinoma · Embryonal Carcinoma · Immature Teratoma·Matched via name phrase
- NCT03067181·RECRUITING·Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
Not reviewed·Conditions: Childhood Extracranial Germ Cell Tumor · Extragonadal Embryonal Carcinoma · Germ Cell Tumor · Malignant Germ Cell Tumor·Matched via name phrase
- NCT07199699·NOT YET RECRUITING·Subxiphoid VATS for Giant Mediastinal Teratoma
Not reviewed·Conditions: Teratomas · Mediastinal ( Chest) Masses · VATS·Matched via name phrase
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 1 · after dedupe 1 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 1 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Uncertain / not reviewed (1)
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Teratoma of the central nervous system — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Teratoma of the central nervous system" OR "Teratoma of central nervous system" OR "CNS teratoma" OR "central nervous system teratoma" OR "teratoma of CNS" OR "teratoma of the CNS"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Teratoma of the central nervous system" OR "Teratoma of central nervous system" OR "CNS teratoma" OR "central nervous system teratoma" OR "teratoma of CNS" OR "teratoma of the CNS"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 6 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"teratoma"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T10:58:05.609Z