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ORPHA:251663

Anaplastic oligoastrocytoma, dual genotype

low confidenceDisorder

Also known as: Anaplastic oligoastrocytoma, dual genotype NEC · Anaplastic oligoastrocytoma, dual genotype, not elsewhere classified · aMOA

Publications

1,821

Trials

36

Interventional, condition-specific

Researchers

1,400

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare and aggressive glial tumor of the central nervous system, that usually presents in adults with , is most often located in the cerebral hemispheres and that is associated with a very poor prognosis.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

WHO grade III mixed glioma · anaplastic mixed glioma · anaplastic oligoastrocytoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,821 matched papers (852 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    36 matched on ClinicalTrials.gov (2 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

1,821

1,821 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

1,821 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

852 in the last 10 years · low confidence

Phrase hits: 1,821 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,400

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang J6 papers · 2023

    Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Zhengzhou, China.

    Papers in Europe PMC
  2. 02
    Wang Y6 papers · 2023

    Department of Endocrinology, The Ninth People's Hospital of Chongqing, Chongqing, 400799, China. wangyi-med@sohu.com.

    Papers in Europe PMC
  3. 03
    Huang Y5 papers · 2025

    Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, Shantou, China.

    Papers in Europe PMC
  4. 04
    Li H4 papers · 2025

    Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.

    Papers in Europe PMC
  5. 05
    Li J4 papers · 2025

    Department of Clinical Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

    Papers in Europe PMC
  6. 06
    Lin S4 papers · 2026

    Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100500, China. Email: linsong2005@126.com.

    Papers in Europe PMC
  7. 07
    Liu J4 papers · 2024

    Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, P.R. China.

    Papers in Europe PMC
  8. 08
    Yang Z4 papers · 2026

    Pathology Department of the First Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

    Papers in Europe PMC
  9. 09
    Zhang H4 papers · 2022

    Department of Pediatrics , Baylor College of Medicine, Houston, TX,

    Papers in Europe PMC
  10. 10
    Chang JH3 papers · 2023

    Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea. ; Neuro-Oncology Clinic, Yonsei University College of Medicine, Seoul, Korea. ; Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

36

interventional trials for this specific condition

36 interventional trials matched this specific condition name; 2 currently recruiting in our sample. 26 trials are registered for oligoastrocytoma, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

36 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 96.1th percentile).

low confidence · 96.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

36 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: oligoastrocytoma

26

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Observational and natural-history studies

3 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Anaplastic oligoastrocytoma, dual genotype" OR "Anaplastic oligoastrocytoma, dual genotype NEC" OR "Anaplastic oligoastrocytoma, dual genotype, not elsewhere classified" OR "WHO grade III mixed glioma" OR "anaplastic mixed glioma" OR "anaplastic oligoastrocytoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Anaplastic oligoastrocytoma, dual genotype" OR "Anaplastic oligoastrocytoma, dual genotype NEC" OR "Anaplastic oligoastrocytoma, dual genotype, not elsewhere classified" OR "WHO grade III mixed glioma" OR "anaplastic mixed glioma" OR "anaplastic oligoastrocytoma"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 36 interventional · 3 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"oligoastrocytoma"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: aMOA

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1821) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T10:51:57.319Z