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ORPHA:247203

Collecting duct carcinoma

low confidenceDisorder

Also known as: BDC · Bellini carcinoma · Bellini duct carcinoma · CDC

Publications

1,993

Trials

11

Interventional, condition-specific

Researchers

1,338

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Collecting duct carcinoma is a rare, aggressive subtype of renal cell carcinoma, which originates from the epithelium of the distal collecting ducts, and usually manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Patients are often asymptomatic for long periods of time and therefore, disease is often locally advanced or metastatic at the time of diagnosis. In cases with metastatic spread, bone pain, cough, dyspnea, pneumonia or neurological compromise may be associated.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (15)

cDC · carcinoma of collecting duct of renal tubule · carcinoma of collecting ducts of Bellini · carcinoma of kidney collecting duct · carcinoma of renal collecting duct · carcinoma of the collecting ducts of Bellini · carcinoma of the kidney collecting duct · carcinoma of the renal collecting duct · collecting duct carcinoma · collecting duct of renal tubule carcinoma · collecting duct renal cancer · collecting duct renal cell carcinoma · kidney collecting duct carcinoma · renal carcinoma, collecting duct type · renal collecting duct carcinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,993 matched papers (1,095 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    11 matched on ClinicalTrials.gov (3 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

11

Drugs / clinical candidates · MONDO_0005220

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,993

1,993 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,993 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

1,095 in the last 10 years · low confidence

Phrase hits: 1,993 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,338

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Liu Y9 papers · 2026

    Department of Gastrointestinal Surgery, Peking University First Hospital, Peking University, Beijing, China.

    Papers in Europe PMC
  2. 02
    Wang H8 papers · 2025

    Department of Urology; Department of Pathology, Temple University Hospital, 3401 N, Broad Street, Philadelphia, PA 19147, USA.

    Papers in Europe PMC
  3. 03
    Xu H6 papers · 2026

    Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

    Papers in Europe PMC
  4. 04
    Yang X6 papers · 2026

    Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yxq11964@rjh.com.cn.

    Papers in Europe PMC
  5. 05
    Zhou L6 papers · 2026

    Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zhouluting@163.com.

    Papers in Europe PMC
  6. 06
    Chen J5 papers · 2026

    State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.

    Papers in Europe PMC
  7. 07
    Li Y5 papers · 2025

    Nephrology Department of Chongqing Hospital of Traditional Chinese Medicine, China.

    Papers in Europe PMC
  8. 08
    Procopio G5 papers · 2026

    Genitourinary Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

    Papers in Europe PMC
  9. 09
    Verzoni E5 papers · 2026

    Genitourinary Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

    Papers in Europe PMC
  10. 10
    Wang C5 papers · 2026

    Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wangchaofu@126.com.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

11

interventional trials for this specific condition

11 interventional trials matched this specific condition name; 3 currently recruiting in our sample.

Data as of 11 September 2026

11 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 92.8th percentile).

low confidence · 92.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

11 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 3 · after dedupe 3 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 3 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (3)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Collecting duct carcinoma — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Collecting duct carcinoma" OR "Bellini carcinoma" OR "Bellini duct carcinoma" OR "carcinoma of collecting duct of renal tubule" OR "carcinoma of the collecting duct of the renal tubule" OR "carcinoma of collecting ducts of Bellini" OR "carcinoma of the collecting ducts of the Bellini" OR "carcinoma of kidney collecting duct" OR "carcinoma of the kidney collecting duct" OR "carcinoma of renal collecting duct" OR "carcinoma of the renal collecting duct" OR "carcinoma of the collecting ducts of Bellini" OR "collecting duct of renal tubule carcinoma" OR "collecting duct of the renal tubule carcinoma" OR "collecting duct renal cancer" OR "collecting duct renal cell carcinoma" OR "kidney collecting duct carcinoma" OR "renal carcinoma, collecting duct type" OR "renal collecting duct carcinoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Collecting duct carcinoma" OR "Bellini carcinoma" OR "Bellini duct carcinoma" OR "carcinoma of collecting duct of renal tubule" OR "carcinoma of the collecting duct of the renal tubule" OR "carcinoma of collecting ducts of Bellini" OR "carcinoma of the collecting ducts of the Bellini" OR "carcinoma of kidney collecting duct" OR "carcinoma of the kidney collecting duct" OR "carcinoma of renal collecting duct" OR "carcinoma of the renal collecting duct" OR "carcinoma of the collecting ducts of Bellini" OR "collecting duct of renal tubule carcinoma" OR "collecting duct of the renal tubule carcinoma" OR "collecting duct renal cancer" OR "collecting duct renal cell carcinoma" OR "kidney collecting duct carcinoma" OR "renal carcinoma, collecting duct type" OR "renal collecting duct carcinoma"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 11 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: BDC; CDC

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 2 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1993) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T10:30:12.315Z