RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:247165

Infantile mercury poisoning

high confidenceDisorder

Also known as: Erythroedema polyneuritis · Feer disease · Infantile acrodynia · Infantile mercury intoxication · Pink disease · Swift disease · Swift-Feer disease

Publications

765

76.3th percentile

Trials

0

Interventional, condition-specific

Researchers

1,089

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

mercury poisoning is a rare intoxication affecting children, most commonly characterized by erythema of the hands, feet and nose, edematous, painful, pink to red, desquamating fingers and toes, bluish, cold and wet extremities, excessive sweating, irritability, photophobia, muscle weakness, diffuse , paresthesia, hypertension and tachycardia, due to elemental, organic or inorganic mercury exposure. Additional manifestations include alopecia, loss of appetite, excessive salivation with red and swollen gums, tooth and nail loss and insomnia.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

erythroedema polyneuritis · infantile acrodynia · infantile mercury intoxication · pink disease

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    765 matched papers (174 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPartial

    None under the specific name; 122 for broader category poisoning

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

765

765 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

765 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

174 in the last 10 years · high confidence · 76.3th percentile (publications denominator)

Phrase hits: 755 · MeSH hits: 16

Open Europe PMC search

Who's working on it?

1,089

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Zhang X6 papers · 2025

    Department of Radiology, Zhongshan Hospital Affiliated to Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

    Papers in Europe PMC
  2. 02
    Chen Y4 papers · 2025

    Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

    Papers in Europe PMC
  3. 03
    Wang J4 papers · 2026

    Department of Basic Medical Sciences, Laboratory of Anatomy, Zhengzhou University, Zhengzhou, 450001 Henan Province China.

    Papers in Europe PMC
  4. 04
    Wang L4 papers · 2025

    Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, Shandong Province, China.

    Papers in Europe PMC
  5. 05
    Wang Y4 papers · 2025

    Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

    Papers in Europe PMC
  6. 06
    Austin DW3 papers · 2014

    School of Psychology, Deakin University, Victoria.

    Papers in Europe PMC
  7. 07
    Caballero-Mellado J3 papers · 2012
    Papers in Europe PMC
  8. 08
    Huang J3 papers · 2026

    Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Diseases, Nanchang, China.

    Papers in Europe PMC
  9. 09
    Huang Y3 papers · 2025

    Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, China.

    Papers in Europe PMC
  10. 10
    Kuo HC3 papers · 2020

    Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Niaosong, Kaohsiung 83301, Taiwan. erickuo48@yahoo.com.tw.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 122 trials are registered for poisoning, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.

high confidence · 36.5th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

122 interventional trials matched poisoning, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: poisoning

122

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Infantile mercury poisoning" OR "Erythroedema polyneuritis" OR "Feer disease" OR "Infantile acrodynia" OR "Infantile mercury intoxication" OR "Pink disease" OR "Swift disease" OR "Swift-Feer disease"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Acrodynia

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Infantile mercury poisoning" OR "Erythroedema polyneuritis" OR "Feer disease" OR "Infantile acrodynia" OR "Infantile mercury intoxication" OR "Pink disease" OR "Swift disease" OR "Swift-Feer disease" OR "Acrodynia"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"poisoning"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T10:29:44.412Z