ORPHA:2374
Isolated congenital laryngeal web
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
372
76.3th percentile
Trials
0
Interventional, condition-specific
Researchers
879
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A rare laryngeal characterized by a membrane-like structure of variable thickness that extends across the laryngeal lumen, between the vocal cords.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0007880
- MeSH:C537676
- MeSH:C563636
- OMIM:150360
- UMLS:C1835494
- NCIT:C98970
Additional Mondo synonyms (1)
Laryngeal web
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
372 matched papers (173 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
372
372 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
372 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
173 in the last 10 years · high confidence · 76.3th percentile (publications denominator)
Phrase hits: 372 · MeSH hits: 0
Who's working on it?
879
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01
- 02Gupta A4 papers · 2019
Department of Anesthesia and Intensive care, Pandit Madan Mohan Malviya Hospital, New Delhi, India.
Papers in Europe PMC - 03Wang J4 papers · 2025
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Email: wmzi2002@163.com.
Papers in Europe PMC - 04Chen X3 papers · 2021
Department of Otolaryngology Head and Neck Surgery，Beijing Tongren Hospital，Capital Medical University.
Papers in Europe PMC - 05Gupta N3 papers · 2023
Department of Pediatric Intensive Care, Sir Ganga Ram Hospital, New Delhi, India.
Papers in Europe PMC - 06Han D3 papers · 2014
Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Papers in Europe PMC - 07Izadi F3 papers · 2019
Otolaryngology Head and Neck Surgery, Ear, Nose, Throat, Head and Neck Research Center, Hazrat Rasoul Akram Hospital, Tehran, Iran.
Papers in Europe PMC - 08Li X3 papers · 2026
Department of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, No. 24, Lane 1400, West Beijing Road, Shanghai, 200040, P.R. China. chhshent@126.com.
Papers in Europe PMC - 09McDonald-McGinn DM3 papers · 2024
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Papers in Europe PMC - 10Sandu K3 papers · 2021
Head and Neck Surgery Department, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Isolated congenital laryngeal web" OR "Laryngeal web"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Isolated congenital laryngeal web" OR "Laryngeal web" OR "laryngeal disorder"
Recall-expansion terms: laryngeal disorder
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T20:00:41.639Z