ORPHA:231457
Acute pandysautonomia
Also known as: Acute panautonomic Guillain-Barré syndrome · Acute panautonomic neuropathy · Acute panautonomic GBS
Clinical definition (Orphanet)
A rare variant of Guillain-Barré syndrome characterized by acute post-ganglionic sympathetic and parasympathetic failure presenting several weeks after acute infection with gastrointestinal symptoms (abdominal pain, vomiting, constipation, diarrhea, gastroparesis, ileus), orthostatic hypotension, erectile dysfunction, urinary frequency, urgency or retention, vasomotor instability with acrocyanosis and reduced salivation, lacrimation and sweating.
Is anyone studying this?
461
461 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
461 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
219 in the last 10 years · medium confidence · 81.4th percentile (publications denominator)
Is a treatment being tested?
0
trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 26 July 2026
No matched interventional trials. This is true for 59.2% of diseases in the trials denominator (151 of 255). Here are the researchers publishing on it.
medium confidence · 29.6th percentile (trials denominator)
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Who's working on it?
948
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Yuki N5 papers · 2016
Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine, 14 Medical Drive, Singapore 117599, Singapore.
Papers in Europe PMC - 02Nakane S4 papers · 2024
Department of Neurology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Papers in Europe PMC - 03Hirata K3 papers · 2016
Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
Papers in Europe PMC - 04Hirohata S3 papers · 2026
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Japan.
Papers in Europe PMC - 05Kikuchi H3 papers · 2026
Department of Microbiology and Immunology, Teikyo University School of Medicine, Japan. Electronic address: hiro-k@med.teikyo-u.ac.jp.
Papers in Europe PMC - 06Koike H3 papers · 2024
Department of Neurology, Nagoya University Graduate School of Medicine, Japan.
Papers in Europe PMC - 07Kon T3 papers · 2018
Department of Neurology, Aomori Prefectural Central Hospital, Japan.
Papers in Europe PMC - 08Robertson D3 papers · 2019
Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Papers in Europe PMC - 09Sawada T3 papers · 2026
Department of Rheumatology, Tokyo Medical University, Japan.
Papers in Europe PMC - 10Tomiyama M3 papers · 2018
Department of Neurology, Aomori Prefectural Central Hospital, Japan.
Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it above — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Acute pandysautonomia" OR "Acute panautonomic Guillain-Barré syndrome" OR "Acute panautonomic neuropathy" OR "Acute panautonomic GBS" OR "acute panautonomic Guillain-Barre syndrome" OR "autoimmune autonomic neuropathy" OR "idiopathic subacute autonomic neuropathy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Acute pandysautonomia" OR "Acute panautonomic Guillain-Barré syndrome" OR "Acute panautonomic neuropathy" OR "Acute panautonomic GBS" OR "acute panautonomic Guillain-Barre syndrome" OR "autoimmune autonomic neuropathy" OR "idiopathic subacute autonomic neuropathy"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): UMLS:C2315246
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: AAG
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus