ORPHA:231426
Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome
Also known as: PCB variant of GBS · PCB variant of Guillain-Barré syndrome · Pharyngeal-cervical-brachial weakness · Pharyngo-cervico-brachial variant of GBS · Pharyngo-cervico-brachial variant of Guillain-Barré syndrome
Publications
201
68th percentile
Trials
0
Interventional, condition-specific
Researchers
832
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome is a rare, acquired peripheral disease characterized by rapidly oropharyngeal (facial palsy, dysarthria) and cervicobrachial weakness, associated with upper limb weakness and hypo/areflexia, in the absence of ophthalmoplegia, , altered consciousness, and prominent lower limb weakness. The presence of monospecific IgG anti-GT1a antibodies is associated.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0016496
- UMLS:C5190783
Additional Mondo synonyms (5)
PCB variant of Guillain-Barre syndrome · pharyngeal-cervical-brachial weakness · pharyngo-cervico-brachial variant of GBS · pharyngo-cervico-brachial variant of Guillain-Barre syndrome · pharyngo-cervico-brachial variant of Guillain-Barré syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
201 matched papers (109 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
201
201 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
201 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
109 in the last 10 years · high confidence · 68th percentile (publications denominator)
Phrase hits: 201 · MeSH hits: 0
Who's working on it?
832
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Yuki N27 papers · 2016
Department of Medicine, National University of Singapore, Singapore. yuki.research@gmail.com
Papers in Europe PMC - 02Koga M15 papers · 2015
Department of Neurology and Clinical Neuroscience Yamaguchi University School of Medicine, Yamaguchi, Japan. kogamrk@dokkyomed.ac.jp
Papers in Europe PMC - 03Hirata K10 papers · 2016
Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
Papers in Europe PMC - 04Kusunoki S4 papers · 2019
Department of Neurology, School of Medicine, Kinki University, Osaka, Japan.
Papers in Europe PMC - 05Nagashima T4 papers · 2016
Department of Neurology, Dokkyo University School of Medicine.
Papers in Europe PMC - 06Odaka M4 papers · 2007
Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293, Japan. m-odaka@dokkyomed.ac.jp
Papers in Europe PMC - 07Wakerley BR4 papers · 2016
Department of Neurology, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK.
Papers in Europe PMC - 08Wu X4 papers · 2026
Department of Neurology, Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, Changchun, 130021, China. wuxiujuan861003@jlu.edu.cn.
Papers in Europe PMC - 09Liu K3 papers · 2025
Department of Pediatric Neurology, The Affiliated Hospital of Qingdao University, No. 1677 Wutaishan Road, Qingdao, Shandong, 266000, China.
Papers in Europe PMC - 10Wang Y3 papers · 2023
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome" OR "Pharyngeal-cervical-brachial variant of the Guillain-Barré syndrome" OR "PCB variant of GBS" OR "PCB variant of the GBS" OR "PCB variant of Guillain-Barré syndrome" OR "PCB variant of the Guillain-Barré syndrome" OR "Pharyngeal-cervical-brachial weakness" OR "Pharyngo-cervico-brachial variant of GBS" OR "Pharyngo-cervico-brachial variant of the GBS" OR "Pharyngo-cervico-brachial variant of Guillain-Barré syndrome" OR "Pharyngo-cervico-brachial variant of the Guillain-Barré syndrome" OR "PCB variant of Guillain-Barre syndrome" OR "PCB variant of the Guillain-Barre syndrome" OR "pharyngo-cervico-brachial variant of Guillain-Barre syndrome" OR "pharyngo-cervico-brachial variant of the Guillain-Barre syndrome"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome" OR "Pharyngeal-cervical-brachial variant of the Guillain-Barré syndrome" OR "PCB variant of GBS" OR "PCB variant of the GBS" OR "PCB variant of Guillain-Barré syndrome" OR "PCB variant of the Guillain-Barré syndrome" OR "Pharyngeal-cervical-brachial weakness" OR "Pharyngo-cervico-brachial variant of GBS" OR "Pharyngo-cervico-brachial variant of the GBS" OR "Pharyngo-cervico-brachial variant of Guillain-Barré syndrome" OR "Pharyngo-cervico-brachial variant of the Guillain-Barré syndrome" OR "PCB variant of Guillain-Barre syndrome" OR "PCB variant of the Guillain-Barre syndrome" OR "pharyngo-cervico-brachial variant of Guillain-Barre syndrome" OR "pharyngo-cervico-brachial variant of the Guillain-Barre syndrome"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T10:17:20.486Z