RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:221098

Glossopharyngeal neuralgia

low confidenceDisorder

Publications

1,441

Trials

3

Interventional, condition-specific

Researchers

922

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare cranial neuralgia characterized by paroxysmal, usually unilateral stabbing pain within the sensory distributions of the auricular and pharyngeal branches of the glossopharyngeal and sometimes the vagus nerve (i. e. the posterior part of the tongue, the tonsillar fossa, oropharynx, larynx, angle of the mandible, and/or ear). The attacks last seconds to minutes with intervals between the paroxysms ranging from a few minutes to a few hours, and appear in clusters lasting weeks to months, again with irregular intervals in between. Pain attacks are usually triggered by a specific stimulus but may also occur spontaneously. The condition can sometimes be associated with bradycardia, syncope, , and even asystole, and is then termed vagoglossopharyngeal neuralgia.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

Glossovasopharyngeal neuralgia · glossopharyngeal nerve neuralgia · glossopharyngeal neuralgia · neuralgia of glossopharyngeal nerve

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,441 matched papers (670 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    3 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

1,441

1,441 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

1,441 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

670 in the last 10 years · low confidence

Phrase hits: 1,441 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

922

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Chen Y4 papers · 2026

    Department of Neurosurgery, The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu.

    Papers in Europe PMC
  2. 02
    Li Y4 papers · 2026

    Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

    Papers in Europe PMC
  3. 03
    Liu J4 papers · 2025

    Department of Neurosurgery, Chongqing General Hospital, Chongqing, China.

    Papers in Europe PMC
  4. 04
    Wang L4 papers · 2024

    Neurosurgery Department, The Fourth Affiliated Hospital, Medicine College of Zhejiang University, Yiwu, Zhejiang, China.

    Papers in Europe PMC
  5. 05
    Acerbi F3 papers · 2026

    Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Unit of Neurosurgery, University Hospital of Pisa, Pisa, Italy.

    Papers in Europe PMC
  6. 06
    Broggi M3 papers · 2026

    Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy.

    Papers in Europe PMC
  7. 07
    Falco J3 papers · 2026

    Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy.

    Papers in Europe PMC
  8. 08
    Ferroli P3 papers · 2026

    Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy.

    Papers in Europe PMC
  9. 09
    Honey CR3 papers · 2024

    Division of Neurosurgery, University of British Columbia, Vancouver, Canada.

    Papers in Europe PMC
  10. 10
    Liu Q3 papers · 2024

    Department of Anesthesiology, First People's Hospital, Zigong, Sichuan, People's Republic of China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

3

interventional trials for this specific condition

3 interventional trials matched this specific condition name; none in our sample are currently recruiting. 377 trials are registered for neuralgia, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

3 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 85.1th percentile).

low confidence · 85.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

3 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: neuralgia

377

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

2 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Glossopharyngeal neuralgia" OR "Glossovasopharyngeal neuralgia" OR "glossopharyngeal nerve neuralgia" OR "neuralgia of glossopharyngeal nerve" OR "neuralgia of the glossopharyngeal nerve"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Glossopharyngeal neuralgia" OR "Glossovasopharyngeal neuralgia" OR "glossopharyngeal nerve neuralgia" OR "neuralgia of glossopharyngeal nerve" OR "neuralgia of the glossopharyngeal nerve"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 3 interventional · 2 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"neuralgia"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1441) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T09:56:59.566Z