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ORPHA:217622

Sensorineural deafness with dilated cardiomyopathy

low confidenceDisorder

Also known as: Neurosensory deafness with dilated cardiomyopathy · Neurosensory hearing loss with dilated cardiomyopathy · Sensorineural hearing loss with dilated cardiomyopathy

Query health: suspect — Only one of 2 strategies returned hits (phrase).

Publications

1,422

Trials

0

Interventional, condition-specific

Researchers

129

Distinct authors in sample

Gene link

EYA4

Moderate

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

Sensorineural deafness with dilated is an extremely rare syndrome described in two families to date and characterized by moderate to severe sensorineural hearing loss manifesting during childhood, and associated with late-onset dilated that generally progresses to heart failure.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (10)

CMD1J · EYA4 familial dilated cardiomyopathy · cardiomyopathy, dilated, type 1J · dilated cardiomyopathy 1J · dilated cardiomyopathy type 1J · familial dilated cardiomyopathy caused by mutation in EYA4 · neurosensory deafness with dilated cardiomyopathy · neurosensory hearing loss with dilated cardiomyopathy · sensorineural deafness with dilated cardiomyopathy · sensorineural hearing loss with dilated cardiomyopathy

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.

  1. Gene identifiedPresent

    Moderate — EYA4

  2. LiteraturePresent

    1,422 matched papers (937 in last 10 years) Source

  3. Phenotype characterisedPresent

    11 HPO annotations (e.g. Dilated cardiomyopathy; Abnormal left ventricular function; Sudden cardiac death) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPartial

    None under the specific name; 136 for broader category dilated cardiomyopathy

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Probably — there is moderate evidence for EYA4.

GenCC classification: Moderate.

Phenotypes (Monarch / HPO)

11

Associated phenotypes · MONDO:0011541

  • Dilated cardiomyopathy
  • Abnormal left ventricular function
  • Sudden cardiac death
  • Sensorineural hearing impairment
  • Congestive heart failure

Showing 5 of 11 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

1,422

1,422 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,422 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

937 in the last 10 years · low confidence

Phrase hits: 19 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

129

Distinct author names in 19 sampled papers — named people below.

Who's working on it?

No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.

  1. 01
    Arbustini Eloisa AE2 papers · 2005

    Molecular Diagnostic Laboratory, IRCCS Policlinico San Matteo, Via Forlanini 16, 27100 Pavia, Italy. e.arbustini@smatteo.pv.it

    Papers in Europe PMC
  2. 02
    Diegoli M2 papers · 2005
    Papers in Europe PMC
  3. 03
    Grasso M2 papers · 2005
    Papers in Europe PMC
  4. 04
    Pasotti M2 papers · 2005
    Papers in Europe PMC
  5. 05
    Ankleshwaria C1 paper · 2022

    Department of Internal Medicine, Civil Hospital Ahmedabad, Gujarat, India.

    Papers in Europe PMC
  6. 06
    Aurino S1 paper · 2010
    Papers in Europe PMC
  7. 07
    Barati S1 paper · 2019
    Papers in Europe PMC
  8. 08
    Beckmann JS1 paper · 2001
    Papers in Europe PMC
  9. 09
    Bénaïche A1 paper · 2001
    Papers in Europe PMC
  10. 10
    Benson KF1 paper · 2002

    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA. kfbenson@u.washington.edu

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

0

interventional trials for this specific condition

No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 136 trials are registered for dilated cardiomyopathy, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026 · last trial check 11 September 2026

No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.

low confidence · 38.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.

136 interventional trials matched dilated cardiomyopathy, the broader category — listed below. Those studies are not counted in the condition-specific total.

Broader category: dilated cardiomyopathy

136

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Sensorineural deafness with dilated cardiomyopathy — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

("Sensorineural deafness with dilated cardiomyopathy" OR "Neurosensory deafness with dilated cardiomyopathy" OR "Neurosensory hearing loss with dilated cardiomyopathy" OR "Sensorineural hearing loss with dilated cardiomyopathy" OR "CMD1J" OR "EYA4 familial dilated cardiomyopathy" OR "cardiomyopathy, dilated, type 1J" OR "dilated cardiomyopathy 1J" OR "dilated cardiomyopathy type 1J" OR "familial dilated cardiomyopathy caused by mutation in EYA4") OR (MESH:"Cardiomyopathy, Dilated, 1J") OR ("EYA4" OR "EYA4 syndrome" OR "EYA4-related")

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Cardiomyopathy, Dilated, 1J

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Sensorineural deafness with dilated cardiomyopathy" OR "Neurosensory deafness with dilated cardiomyopathy" OR "Neurosensory hearing loss with dilated cardiomyopathy" OR "Sensorineural hearing loss with dilated cardiomyopathy" OR "CMD1J" OR "EYA4 familial dilated cardiomyopathy" OR "cardiomyopathy, dilated, type 1J" OR "dilated cardiomyopathy 1J" OR "dilated cardiomyopathy type 1J" OR "familial dilated cardiomyopathy caused by mutation in EYA4" OR "Cardiomyopathy, Dilated, 1J"

Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"dilated cardiomyopathy"

Query health: suspect — strategies attempted: phrase, mesh; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (1422) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-27T09:52:02.024Z