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ORPHA:213787

Carcinosarcoma of the cervix uteri

high confidenceDisorder

Also known as: Cervical carcinosarcoma · Cervical malignant Müllerian mixed tumor · Malignant Müllerian mixed tumor of the cervix uteri

Publications

83

53.9th percentile

Trials

1

Interventional, condition-specific

Researchers

506

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Carcinosarcoma of the cervix uteri is a rare, malignant, mixed epithelial and mesenchymal tumor, located in the cervix uteri, composed of an admixture of carcinomatous and sarcomatous elements. It usually presents with abnormal vaginal bleeding and a round, well-defined, grey to yellowish-white, pedunculated polypoid mass protruding through the cervical canal. Association with HPV infection (especially serotype 16) has been frequently reported.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (17)

carcinosarcoma of the cervix uteri · cervical carcinosarcoma · cervical malignant Mullerian mixed tumor · cervical malignant Mullerian mixed tumour · cervical malignant Müllerian mixed tumor · cervical malignant Müllerian mixed tumour · cervical malignant mixed Mullerian tumour · cervical malignant mixed mesodermal (Mullerian) tumor · cervical malignant mixed mesodermal (Mullerian) tumour · cervical malignant mixed mesodermal (Müllerian) tumor · cervical malignant mixed mesodermal (Müllerian) tumour · cervical malignant mixed mesodermal mullerian tumour · malignant Mullerian mixed tumor of the cervix uteri · malignant Mullerian mixed tumour of the cervix uteri · malignant Müllerian mixed tumor of the cervix uteri · malignant Müllerian mixed tumour of the cervix uteri · uterine cervix carcinosarcoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    83 matched papers (52 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

83

83 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

83 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

52 in the last 10 years · high confidence · 53.9th percentile (publications denominator)

Phrase hits: 83 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

506

Distinct author names in 83 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Hayashi T3 papers · 2025

    1Cancer Medicine, National Hospital Organization, Kyoto Medical Center, Kyoto 612-8555, Japan.

    Papers in Europe PMC
  2. 02
    Li L3 papers · 2025

    Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Zhengzhou, 450052, Henan, China.

    Papers in Europe PMC
  3. 03
    Shao L3 papers · 2021

    Burning Rock Biotech, Guangzhou, China.

    Papers in Europe PMC
  4. 04
    Yasuda M3 papers · 2019

    Departments of Pathology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1128, Japan

    Papers in Europe PMC
  5. 05
    Abiko K2 papers · 2025

    2Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Ishikawa, 920-8641, Japan.

    Papers in Europe PMC
  6. 06
    Albert A2 papers · 2020

    Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA. ashley.grv@gmail.com.

    Papers in Europe PMC
  7. 07
    Georgescu TA2 papers · 2021

    Discipline of Pathology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

    Papers in Europe PMC
  8. 08
    Han-Zhang H2 papers · 2021

    Burning Rock Biotech, Guangzhou, China.

    Papers in Europe PMC
  9. 09
    Konishi I2 papers · 2025

    3Department of Obstetrics and Gynecology, Kyoto University School of Medicine, Kyoto 606-8507 Japan.

    Papers in Europe PMC
  10. 10
    Lee JW2 papers · 2023

    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting. 83 trials are registered for carcinosarcoma, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).

high confidence · 76.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: carcinosarcoma

83

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Carcinosarcoma of the cervix uteri" OR "Carcinosarcoma of cervix uteri" OR "Cervical carcinosarcoma" OR "Cervical malignant Müllerian mixed tumor" OR "Malignant Müllerian mixed tumor of the cervix uteri" OR "Malignant Müllerian mixed tumor of cervix uteri" OR "cervical malignant Mullerian mixed tumor" OR "cervical malignant Mullerian mixed tumour" OR "cervical malignant Müllerian mixed tumour" OR "cervical malignant mixed Mullerian tumour" OR "cervical malignant mixed mesodermal (Mullerian) tumor" OR "cervical malignant mixed mesodermal (Mullerian) tumour" OR "cervical malignant mixed mesodermal (Müllerian) tumor" OR "cervical malignant mixed mesodermal (Müllerian) tumour" OR "cervical malignant mixed mesodermal mullerian tumour" OR "malignant Mullerian mixed tumor of the cervix uteri" OR "malignant Mullerian mixed tumor of cervix uteri" OR "malignant Mullerian mixed tumour of the cervix uteri" OR "malignant Mullerian mixed tumour of cervix uteri" OR "malignant Müllerian mixed tumour of the cervix uteri" OR "malignant Müllerian mixed tumour of cervix uteri" OR "uterine cervix carcinosarcoma"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Carcinosarcoma of the cervix uteri" OR "Carcinosarcoma of cervix uteri" OR "Cervical carcinosarcoma" OR "Cervical malignant Müllerian mixed tumor" OR "Malignant Müllerian mixed tumor of the cervix uteri" OR "Malignant Müllerian mixed tumor of cervix uteri" OR "cervical malignant Mullerian mixed tumor" OR "cervical malignant Mullerian mixed tumour" OR "cervical malignant Müllerian mixed tumour" OR "cervical malignant mixed Mullerian tumour" OR "cervical malignant mixed mesodermal (Mullerian) tumor" OR "cervical malignant mixed mesodermal (Mullerian) tumour" OR "cervical malignant mixed mesodermal (Müllerian) tumor" OR "cervical malignant mixed mesodermal (Müllerian) tumour" OR "cervical malignant mixed mesodermal mullerian tumour" OR "malignant Mullerian mixed tumor of the cervix uteri" OR "malignant Mullerian mixed tumor of cervix uteri" OR "malignant Mullerian mixed tumour of the cervix uteri" OR "malignant Mullerian mixed tumour of cervix uteri" OR "malignant Müllerian mixed tumour of the cervix uteri" OR "malignant Müllerian mixed tumour of cervix uteri" OR "uterine cervix carcinosarcoma"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"carcinosarcoma"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T09:39:04.825Z