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ORPHA:213512

Malignant mixed Müllerian tumor of the ovary

high confidenceDisorder

Also known as: MMMT of the ovary · Ovarian carcinosarcoma · Ovarian malignant mixed Müllerian tumor · Ovarian malignant mixed epithelial mesenchymal tumor

Publications

966

84.8th percentile

Trials

26

Interventional, condition-specific

Researchers

1,322

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

Malignant mixed Müllerian tumor of the ovary is a rare and very aggressive neoplasm presenting most commonly in postmenopausal women and is composed of adenocarcinomatous and sarcomatous elements and, depending on the types of these elements, can be classified as homologous or heterologous. It often has a poor prognosis.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (41)

carcinosarcoma of ovary · carcinosarcoma of the ovary · malignant mixed mesodermal Mullerian neoplasm of ovary · malignant mixed mesodermal Mullerian neoplasm of the ovary · malignant mixed mesodermal Mullerian tumor of ovary · malignant mixed mesodermal Mullerian tumor of the ovary · malignant mixed mesodermal Mullerian tumour of ovary · malignant mixed mesodermal Mullerian tumour of the ovary · malignant mixed mesodermal Müllerian neoplasm of ovary · malignant mixed mesodermal Müllerian neoplasm of the ovary · malignant mixed mesodermal Müllerian tumor of ovary · malignant mixed mesodermal Müllerian tumor of the ovary · malignant mixed mesodermal Müllerian tumour of ovary · malignant mixed mesodermal Müllerian tumour of the ovary · ovarian MMMT · ovarian carcinosarcoma · ovarian malignant mesodermal (Mullerian) mixed tumor · ovarian malignant mesodermal (Mullerian) mixed tumour · ovarian malignant mesodermal (Müllerian) mixed tumor · ovarian malignant mesodermal (Müllerian) mixed tumour · ovarian malignant mesodermal (mullerian) mixed tumor · ovarian malignant mesodermal (mullerian) mixed tumour · ovarian malignant mixed Mullerian neoplasm · ovarian malignant mixed Mullerian tumor · ovarian malignant mixed Mullerian tumour · ovarian malignant mixed Müllerian neoplasm · ovarian malignant mixed Müllerian tumor · ovarian malignant mixed Müllerian tumour · ovarian malignant mixed epithelial mesenchymal tumor · ovarian malignant mixed epithelial mesenchymal tumour · ovarian malignant mixed mesodermal (Mullerian) tumor · ovarian malignant mixed mesodermal (Mullerian) tumour · ovarian malignant mixed mesodermal (Müllerian) tumor · ovarian malignant mixed mesodermal (Müllerian) tumour · ovarian malignant mixed mesodermal Mullerian neoplasm · ovarian malignant mixed mesodermal Mullerian tumor · ovarian malignant mixed mesodermal Mullerian tumour · ovarian malignant mixed mesodermal Müllerian neoplasm · ovarian malignant mixed mesodermal Müllerian tumor · ovarian malignant mixed mesodermal Müllerian tumour · ovary carcinosarcoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    966 matched papers (591 in last 10 years) Source

  3. Phenotype characterisedNot found

    No HPO disease–phenotype associations via Monarch for these Mondo IDs

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    26 matched on ClinicalTrials.gov (7 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

None returned for this Mondo ID. That often means “not linked under this ID,” not “no clinical features.”

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

9

Drugs / clinical candidates · MONDO_0003792

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

966

966 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

966 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

591 in the last 10 years · high confidence · 84.8th percentile (publications denominator)

Phrase hits: 966 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,322

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Hollis RL6 papers · 2024

    The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK. robb.hollis@ed.ac.uk.

    Papers in Europe PMC
  2. 02
    McNamara B6 papers · 2026

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, United States of America.

    Papers in Europe PMC
  3. 03
    Barker HE5 papers · 2026

    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

    Papers in Europe PMC
  4. 04
    Herrington CS5 papers · 2024

    The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK.

    Papers in Europe PMC
  5. 05
    Ratner E5 papers · 2026

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, United States of America.

    Papers in Europe PMC
  6. 06
    Scott CL5 papers · 2026

    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

    Papers in Europe PMC
  7. 07
    Altwerger G4 papers · 2026

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, United States of America.

    Papers in Europe PMC
  8. 08
    Bellone S4 papers · 2025

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, United States of America.

    Papers in Europe PMC
  9. 09
    Churchman M4 papers · 2024

    The Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK.

    Papers in Europe PMC
  10. 10
    Demirkiran C4 papers · 2025

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, United States of America.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

26

interventional trials for this specific condition

26 interventional trials matched this specific condition name; 7 currently recruiting in our sample.

Data as of 11 September 2026

26 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 95.6th percentile).

high confidence · 95.6th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

26 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 4 · after dedupe 4 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 4 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (4)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Malignant mixed Müllerian tumor of the ovary — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Malignant mixed Müllerian tumor of the ovary" OR "Malignant mixed Müllerian tumor of ovary" OR "MMMT of the ovary" OR "MMMT of ovary" OR "Ovarian carcinosarcoma" OR "Ovarian malignant mixed Müllerian tumor" OR "Ovarian malignant mixed epithelial mesenchymal tumor" OR "carcinosarcoma of ovary" OR "carcinosarcoma of the ovary" OR "malignant mixed mesodermal Mullerian neoplasm of ovary" OR "malignant mixed mesodermal Mullerian neoplasm of the ovary" OR "malignant mixed mesodermal Mullerian tumor of ovary" OR "malignant mixed mesodermal Mullerian tumor of the ovary" OR "malignant mixed mesodermal Mullerian tumour of ovary" OR "malignant mixed mesodermal Mullerian tumour of the ovary" OR "malignant mixed mesodermal Müllerian neoplasm of ovary" OR "malignant mixed mesodermal Müllerian neoplasm of the ovary" OR "malignant mixed mesodermal Müllerian tumor of ovary" OR "malignant mixed mesodermal Müllerian tumor of the ovary" OR "malignant mixed mesodermal Müllerian tumour of ovary" OR "malignant mixed mesodermal Müllerian tumour of the ovary" OR "ovarian MMMT" OR "ovarian malignant mesodermal (Mullerian) mixed tumor" OR "ovarian malignant mesodermal (Mullerian) mixed tumour" OR "ovarian malignant mesodermal (Müllerian) mixed tumor" OR "ovarian malignant mesodermal (Müllerian) mixed tumour" OR "ovarian malignant mixed Mullerian neoplasm" OR "ovarian malignant mixed Mullerian tumor" OR "ovarian malignant mixed Mullerian tumour" OR "ovarian malignant mixed Müllerian neoplasm" OR "ovarian malignant mixed Müllerian tumour" OR "ovarian malignant mixed epithelial mesenchymal tumour" OR "ovarian malignant mixed mesodermal (Mullerian) tumor" OR "ovarian malignant mixed mesodermal (Mullerian) tumour" OR "ovarian malignant mixed mesodermal (Müllerian) tumor" OR "ovarian malignant mixed mesodermal (Müllerian) tumour" OR "ovarian malignant mixed mesodermal Mullerian neoplasm" OR "ovarian malignant mixed mesodermal Mullerian tumor" OR "ovarian malignant mixed mesodermal Mullerian tumour" OR "ovarian malignant mixed mesodermal Müllerian neoplasm"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Malignant mixed Müllerian tumor of the ovary" OR "Malignant mixed Müllerian tumor of ovary" OR "MMMT of the ovary" OR "MMMT of ovary" OR "Ovarian carcinosarcoma" OR "Ovarian malignant mixed Müllerian tumor" OR "Ovarian malignant mixed epithelial mesenchymal tumor" OR "carcinosarcoma of ovary" OR "carcinosarcoma of the ovary" OR "malignant mixed mesodermal Mullerian neoplasm of ovary" OR "malignant mixed mesodermal Mullerian neoplasm of the ovary" OR "malignant mixed mesodermal Mullerian tumor of ovary" OR "malignant mixed mesodermal Mullerian tumor of the ovary" OR "malignant mixed mesodermal Mullerian tumour of ovary" OR "malignant mixed mesodermal Mullerian tumour of the ovary" OR "malignant mixed mesodermal Müllerian neoplasm of ovary" OR "malignant mixed mesodermal Müllerian neoplasm of the ovary" OR "malignant mixed mesodermal Müllerian tumor of ovary" OR "malignant mixed mesodermal Müllerian tumor of the ovary" OR "malignant mixed mesodermal Müllerian tumour of ovary" OR "malignant mixed mesodermal Müllerian tumour of the ovary" OR "ovarian MMMT" OR "ovarian malignant mesodermal (Mullerian) mixed tumor" OR "ovarian malignant mesodermal (Mullerian) mixed tumour" OR "ovarian malignant mesodermal (Müllerian) mixed tumor" OR "ovarian malignant mesodermal (Müllerian) mixed tumour" OR "ovarian malignant mixed Mullerian neoplasm" OR "ovarian malignant mixed Mullerian tumor" OR "ovarian malignant mixed Mullerian tumour" OR "ovarian malignant mixed Müllerian neoplasm" OR "ovarian malignant mixed Müllerian tumour" OR "ovarian malignant mixed epithelial mesenchymal tumour" OR "ovarian malignant mixed mesodermal (Mullerian) tumor" OR "ovarian malignant mixed mesodermal (Mullerian) tumour" OR "ovarian malignant mixed mesodermal (Müllerian) tumor" OR "ovarian malignant mixed mesodermal (Müllerian) tumour" OR "ovarian malignant mixed mesodermal Mullerian neoplasm" OR "ovarian malignant mixed mesodermal Mullerian tumor" OR "ovarian malignant mixed mesodermal Mullerian tumour" OR "ovarian malignant mixed mesodermal Müllerian neoplasm"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 26 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: ovarian malignant mixed mesodermal Müllerian tumor; ovarian malignant mixed mesodermal Müllerian tumour; ovary carcinosarcoma

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T09:33:37.453Z