ORPHA:2073
Narcolepsy type 1
Also known as: Gélineau disease · Hypocretin/orexin deficiency syndrome · Narcolepsy-cataplexy
Publications
5,171
96.5th percentile
Trials
45
Interventional, condition-specific
Researchers
1,053
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare neurologic disease characterized by excessive daytime sleepiness associated with uncontrollable sleep urges and cataplexy (sudden loss of muscle tone while awake, often triggered by pleasant emotions).
How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0016158
- UMLS:C0751362
Additional Mondo synonyms (6)
Gelineau disease · Gelineau syndrome · Gelineau's syndrome · narcolepsy type 1 · narcolepsy with cataplexy · narcolepsy-cataplexy syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
5,171 matched papers (3,284 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
45 matched on ClinicalTrials.gov (17 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
5,171
5,171 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
5,171 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
3,284 in the last 10 years · high confidence · 96.5th percentile (publications denominator)
Phrase hits: 5,171 · MeSH hits: 0
Who's working on it?
1,053
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Dauvilliers Y21 papers · 2026
From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede; Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center; Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands; Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland; Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands; Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.); Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France; Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany; Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia; IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy; Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid; Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain; Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland; Sleep Medicine Center Kempenhaeghe (S.O.), Heeze; Eindhoven University of Technology (S.O.), the Netherlands; Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón; University Complutense of Madrid (R.P.-A.), Spain; Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland; Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal; Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria; Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany; Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic; Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland; Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic; Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain; Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy.
Papers in Europe PMC - 02Plazzi G17 papers · 2026
From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede; Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center; Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands; Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland; Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands; Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.); Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France; Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany; Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia; IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy; Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid; Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain; Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland; Sleep Medicine Center Kempenhaeghe (S.O.), Heeze; Eindhoven University of Technology (S.O.), the Netherlands; Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón; University Complutense of Madrid (R.P.-A.), Spain; Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland; Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal; Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria; Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany; Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic; Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland; Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic; Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain; Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy.
Papers in Europe PMC - 03Barateau L15 papers · 2026
From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede; Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center; Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands; Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland; Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands; Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.); Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France; Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany; Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia; IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy; Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid; Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain; Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland; Sleep Medicine Center Kempenhaeghe (S.O.), Heeze; Eindhoven University of Technology (S.O.), the Netherlands; Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón; University Complutense of Madrid (R.P.-A.), Spain; Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland; Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal; Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria; Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany; Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic; Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland; Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic; Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain; Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy.
Papers in Europe PMC - 04Pizza F13 papers · 2026
From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede; Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center; Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands; Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland; Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands; Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.); Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France; Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany; Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia; IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy; Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid; Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain; Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland; Sleep Medicine Center Kempenhaeghe (S.O.), Heeze; Eindhoven University of Technology (S.O.), the Netherlands; Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón; University Complutense of Madrid (R.P.-A.), Spain; Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland; Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal; Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria; Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany; Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic; Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland; Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic; Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain; Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy.
Papers in Europe PMC - 05Mignot E9 papers · 2026
Stanford Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, California.
Papers in Europe PMC - 06Biscarini F8 papers · 2026
IRCCS - Institute of Neurological Science, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Papers in Europe PMC - 07Arnulf I6 papers · 2026
Sleep Disorders Unit, National Reference Center for Narcolepsies and Hypersomnia, Pitie-Salpetriere Hospital, AP-HP - Sorbonne University, Paris, France; DreamTeam, Paris Brain Institute (ICM), INSERM, CNRS, AP-HP, Paris, France; Sorbonne University, Paris, France. Electronic address: isabelle.arnulf@aphp.fr.
Papers in Europe PMC - 08Franco P6 papers · 2026
Lyon Neuroscience Research Center, CNRS UMR 5292, INSERM U1028, Lyon 1 University, Lyon, France.
Papers in Europe PMC - 09Fronczek R6 papers · 2026
From the Sleep Wake Center SEIN Heemstede (J.K.G., R.F., G.J.L.), Stichting Epilepsie Instellingen Nederland, Heemstede; Department of Neurology and Clinical Neurophysiology (J.K.G., R.F., G.J.L.), Leiden University Medical Center; Department of Anatomy and Neurosciences (J.K.G., S.M.), Amsterdam UMC (Location VUmc), the Netherlands; Center for Sleep Medicine, Sleep Research and Epileptology (Z.Z., R.K.), Klinik Barmelweid AG, Barmelweid, Switzerland; Leiden Observatory (M.S.S.L.O.), Leiden University, the Netherlands; Sleep-Wake Disorders Unit (Y.D., L.B.), Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, and Kleine-Levin Syndrome (Y.D., L.B.); Institute for Neurosciences of Montpellier INM (Y.D., L.B.), Univ Montpellier, INSERM, France; Neurology Department (G.M.), Hephata Klinik, Schwalmstadt, Germany; Department of Biomedical, Metabolic and Neural Sciences (G.P.), University of Modena and Reggio Emilia; IRCCS Istituto delle Scienze Neurologiche di Bologna (G.P, F.P.), Bologna, Italy; Neurophysiology and Sleep Disorders Unit (R.d.R.-V.), Hospital Vithas Nuestra Señora de América, Madrid; Neurology Service (J.S.C.), Institut de Neurociències Hospital Clínic, University of Barcelona, Spain; Neurology Department and Centre of Clinical Neurosciences (K.S.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Helsinki Sleep Clinic (M.P.), Vitalmed Research Center, Finland; Sleep Medicine Center Kempenhaeghe (S.O.), Heeze; Eindhoven University of Technology (S.O.), the Netherlands; Sleep and Epilepsy Unit-Clinical Neurophysiology Service (R.P.-A.), University General Hospital Gregorio Marañón, Research Institute Gregorio Marañón; University Complutense of Madrid (R.P.-A.), Spain; Center for Investigation and Research in Sleep (R.H.), Lausanne University Hospital, Switzerland; Serviço de Neurofisiologia (A.M.d.S.), Hospital Santo António/Centro Hospitalar Universitário do Porto and UMIB-Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, Portugal; Neurology Department (B.H., A.H.), Sleep Disorders Clinic, Innsbruck Medical University, Austria; Department of Clinical Neurophysiology (A.W.), Institute of Psychiatry and Neurology, Warsaw, Poland; Department of Sleep Medicine and Neuromuscular Disorders (A.H.), University of Münster, Germany; Neurology Department (E.F.), Medical Faculty of P.J. Safarik University, University Hospital of L. Pasteur Kosice, Kosice, Slovak Republic; Neurology Department (M.M.), EOC, Ospedale Regionale di Lugano, Ticino, Switzerland; Department of Sleep Medicine (J.B.), National Institute of Mental Health, Klecany, Czech Republic; Fundacio d`Investigacio Sanitaria de les illes balears (F.C.), Hospital Universitari Son Espases, Palma de Mallorca, Spain; Department of Neurology (C.L.B., M.H.S., R.K.), Inselspital, Bern University Hospital, University of Bern, Switzerland; and Department of Biomedical and Neuromotor Sciences (F.P.), University of Bologna, Italy.
Papers in Europe PMC - 10Lammers GJ6 papers · 2026
Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
45
interventional trials for this specific condition
45 interventional trials matched this specific condition name; 17 currently recruiting in our sample. 80 trials are registered for narcolepsy, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
45 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 96.8th percentile).
high confidence · 96.8th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
45 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT07455383·RECRUITING·A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1
Conditions: Narcolepsy Type 1·Matched via name phrase
- NCT06767683·RECRUITING·A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia
Conditions: Narcolepsy Type 1 · Narcolepsy Type 2 · Idiopathic Hypersomnia·Matched via name phrase
- NCT06457945·RECRUITING·Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions
Conditions: Narcolepsy Type 1 · Hypersomnolence · Idiopathic Hypersomnia·Matched via name phrase
- NCT07633301·RECRUITING·A Study of TAK-360 in Adults With Narcolepsy Type 1 (Narcolepsy With Cataplexy)
Conditions: Narcolepsy Type 1·Matched via name phrase
- NCT07006233·RECRUITING·A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia
Conditions: Idiopathic Hypersomnia · Narcolepsy Type 1 (NT 1) · Narcolepsy Type 2 (NT2)·Matched via name phrase
- NCT06484348·RECRUITING·Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia
Conditions: Narcolepsy Type 1 · Idiopathic Hypersomnia·Matched via name phrase
- NCT07363720·RECRUITING·A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy
Conditions: Narcolepsy Type 1 (NT1) · Narcolepsy With Cataplexy·Matched via name phrase
- NCT07598708·RECRUITING·A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence
Conditions: Narcolepsy Type 1 · Narcolepsy Type 2·Matched via name phrase
- NCT06383806·RECRUITING·Decreasing Nightmares in Adults With Narcolepsy
Conditions: Narcolepsy · Narcolepsy Type 1 · Narcolepsy With Cataplexy · Narcolepsy Without Cataplexy·Matched via name phrase
- NCT06752668·RECRUITING·A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
Conditions: Narcolepsy Type 1 · Narcolepsy Type 2 · Idiopathic Hypersomnia·Matched via name phrase
- NCT07584434·RECRUITING·A Phase 1, First-in-human Study of VX-433
Conditions: Narcolepsy Type 1 (NT1)·Matched via name phrase
- NCT05816382·RECRUITING·A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions
Conditions: Narcolepsy Type 1·Matched via name phrase
- NCT07540897·RECRUITING·A Study to Evaluate the Efficacy, Safety and Tolerability of ALKS 2680 in Adults With Narcolepsy Type 1 (Brilliance NT1 - 304)
Conditions: Narcolepsy Type 1·Matched via name phrase
- NCT07365566·RECRUITING·Pain Assessment in Patients With Idiopathic Rapid Eye Movement (REM) Sleep Behaviour Disorder
Conditions: REM Sleep Behavior Disorder (iRBD) · Narcolepsy Type 1·Matched via name phrase
- NCT06809803·RECRUITING·Extended-release Sodium Oxybate in Children
Conditions: Narcolepsy Type 1 (NT 1)·Matched via name phrase
Broader category: narcolepsy
80
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT07625280·NOT YET RECRUITING·A Study Evaluating the Efficacy and Safety of Xywav Expanded Dosing vs Placebo in Participants With Narcolepsy or IH
Conditions: Narcolepsy · Idiopathic Hypersomnia·Matched via name phrase
- NCT07540364·NOT YET RECRUITING·A Phase 3 Study to Evaluate the Efficacy and Safety of Samelisant in Patients With Narcolepsy (AWAKE)
Conditions: Narcolepsy·Matched via name phrase
- NCT06797284·RECRUITING·The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders
Conditions: Insomnia Chronic · Narcolepsy · REM Sleep Behavior Disorder·Matched via name phrase
- NCT07613710·RECRUITING·A Trial to Test the Safety and Tolerability of Lu AH69593 in Adults That Are Healthy or Have Narcolepsy
Conditions: Narcolepsy·Matched via name phrase
- NCT07502443·RECRUITING·A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2
Conditions: Narcolepsy Type 2·Matched via name phrase
- NCT05773872·RECRUITING·Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic Hypersomnia
Conditions: Narcolepsy · Social Cognition·Matched via name phrase
- NCT06952699·RECRUITING·A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
Conditions: Narcolepsy Type 2·Matched via name phrase
- NCT07493265·RECRUITING·A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy
Conditions: Narcolepsy·Matched via name phrase
- NCT07675135·RECRUITING·A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy
Conditions: EDS · Cataplexy · Fatigue · Narcolepsy·Matched via name phrase
Observational and natural-history studies
10 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
- NCT06336057·RECRUITING·Mentalizating in Adults Suffering from Narcolepsy Type 1.
Conditions: Narcolepsy Type 1·Matched via name phrase
- NCT07299097·RECRUITING·Epidemiology of Narcolepsy Type 1 and Type 2 in Spain
Conditions: Narcolepsy Type 1 · Narcolepsy Type 2·Matched via name phrase
- NCT06292598·RECRUITING·Bacterial Translocation and Gut Microbiota in Type 1 Narcolepsy Patients Versus a Control Population
Conditions: Narcolepsy Type 1 · Bacterial Translocation·Matched via name phrase
General rare disease registries you may be eligible for
These studies enroll across many rare conditions. They are not counted as evidence that anyone is studying this specific disease.
- NCT01793168·RECRUITING·Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Conditions: Rare Disorders · Undiagnosed Disorders · Disorders of Unknown Prevalence · Cornelia De Lange Syndrome
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Narcolepsy type 1" OR "Gélineau disease" OR "Hypocretin/orexin deficiency syndrome" OR "Narcolepsy-cataplexy" OR "Gelineau disease" OR "Gelineau syndrome" OR "Gelineau's syndrome" OR "narcolepsy with cataplexy" OR "narcolepsy-cataplexy syndrome"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Narcolepsy type 1" OR "Gélineau disease" OR "Hypocretin/orexin deficiency syndrome" OR "Narcolepsy-cataplexy" OR "Gelineau disease" OR "Gelineau syndrome" OR "Gelineau's syndrome" OR "narcolepsy with cataplexy" OR "narcolepsy-cataplexy syndrome"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 45 interventional · 10 observational · 1 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"narcolepsy"
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T19:02:20.143Z
