ORPHA:2024
Hereditary gingival fibromatosis
Also known as: Autosomal dominant gingival fibromatosis · Autosomal dominant gingival hyperplasia · Hereditary gingival hyperplasia
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
384
75.7th percentile
Trials
1
Interventional, condition-specific
Researchers
939
Distinct authors in sample
Gene link
DUSP8, ZNF862
Limited
Readiness
3/6
Stages with a signal
Clinical definition (Orphanet)
gingival fibromatosis (HGF) is a rare benign, slowly , non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent (or more rarely the primary) dentition or even at birth. It presents as a localized or generalized, smooth or nodular overgrowth of the gingival tissues of varying severity. It can be isolated, with inheritance, or as part of a syndrome.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0016070
- UMLS:C0399440
Additional Mondo synonyms (4)
autosomal dominant gingival fibromatosis · autosomal dominant gingival hyperplasia · hereditary gingival fibromatosis · hereditary gingival hyperplasia
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
3/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedPresent
Limited — DUSP8, ZNF862
- LiteraturePresent
384 matched papers (167 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
1 matched on ClinicalTrials.gov
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Possibly — only limited evidence so far for DUSP8, ZNF862.
GenCC classification: Limited.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
384
384 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
384 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
167 in the last 10 years · high confidence · 75.7th percentile (publications denominator)
Phrase hits: 384 · MeSH hits: 0
Who's working on it?
939
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01
- 02Gawron K7 papers · 2021
Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland. katarzyna.gawron@uj.edu.pl.
Papers in Europe PMC - 03Chomyszyn-Gajewska M6 papers · 2019
b Department of Periodontology and Oral Medicine, Medical College , Jagiellonian University , Krakow , Poland.
Papers in Europe PMC - 04Coletta RD6 papers · 2025
Department of Oral Diagnosis, University of Campinas Dental School, Piracicaba, São Paulo, Brazil. coletta@fop.unicamp.br
Papers in Europe PMC - 05Łazarz-Bartyzel K6 papers · 2021
b Department of Periodontology and Oral Medicine, Medical College , Jagiellonian University , Krakow , Poland.
Papers in Europe PMC - 06Martelli-Júnior H6 papers · 2025
Health Science Programme, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil.
Papers in Europe PMC - 07Potempa J6 papers · 2019
a Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology , Jagiellonian University , Krakow , Poland.
Papers in Europe PMC - 08Bian Z5 papers · 2026
1 The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China.
Papers in Europe PMC - 09Plakwicz P5 papers · 2021
c Department of Periodontology , Medical University of Warsaw , Warsaw , Poland.
Papers in Europe PMC - 10Liu Y4 papers · 2025
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontology, West China Hospital of Stomatology, Sichuan University, No.14, Section 3, Renmin South Road, Chengdu, 610041, China.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
1
interventional trials for this specific condition
1 interventional trial matched this specific condition name; none in our sample are currently recruiting.
Data as of 27 July 2026
1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).
high confidence · 76.8th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
1 interventional trials matched after quoted-phrase search and title/condition post-filter.
No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Hereditary gingival fibromatosis" OR "Autosomal dominant gingival fibromatosis" OR "Autosomal dominant gingival hyperplasia" OR "Hereditary gingival hyperplasia"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Hereditary gingival fibromatosis" OR "Autosomal dominant gingival fibromatosis" OR "Autosomal dominant gingival hyperplasia" OR "Hereditary gingival hyperplasia" OR "DUSP8" OR "ZNF862"
Recall-expansion terms: DUSP8, ZNF862
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T18:47:20.536Z