ORPHA:2004
Laryngotracheoesophageal cleft
Also known as: LC · LTEC · Laryngo-tracheo-esophageal cleft · Laryngo-tracheo-esophageal diastema
Publications
16,903
Trials
3
Interventional, condition-specific
Researchers
1,022
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A laryngo-tracheo-esophageal cleft (LC) is a characterized by an abnormal, posterior, sagittal communication between the larynx and the pharynx, possibly extending downward between the trachea and the esophagus.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0016060
- MeSH:C537875
- NCIT:C98622
Additional Mondo synonyms (6)
Larnygeotracheoesophageal cleft · congenital cleft larynx · laryngeal cleft · laryngo-tracheo-esophageal cleft · laryngo-tracheo-esophageal diastema · tracheal cleft
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
16,903 matched papers (9,159 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPresent
3 matched on ClinicalTrials.gov (2 recruiting in sample)
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
16,903
16,903 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
16,903 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
9,159 in the last 10 years · low confidence
Phrase hits: 16,903 · MeSH hits: 0
Who's working on it?
1,022
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Batra P6 papers · 2026
Department of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Manav Rachna International Institute of Research and Studies, Faridabad, IN, India.
Papers in Europe PMC - 02Davies A6 papers · 2026
The Cleft Collective, Bristol Dental School, The University of Bristol, Bristol, UK.
Papers in Europe PMC - 03Wren Y5 papers · 2026
The Cleft Collective, Bristol Dental School, The University of Bristol, Bristol, UK.
Papers in Europe PMC - 04Flores RL4 papers · 2026
Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY.
Papers in Europe PMC - 05Shetye PR4 papers · 2026
Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY.
Papers in Europe PMC - 06
- 07Bow M3 papers · 2026
Faculty of Medicine and Health, The University of Sydney, New South Wales, Australia, and.
Papers in Europe PMC - 08Bressmann T3 papers · 2026
Department of Speech-Language Pathology, University of Toronto, Ontario, Canada.
Papers in Europe PMC - 09Chong DK3 papers · 2026
From the Department of Plastic and Maxillofacial Surgery, Royal Children's Hospital.
Papers in Europe PMC - 10Das S3 papers · 2026
Department of Orthodontics, SCB Government Dental College, Cuttack, India.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
3
interventional trials for this specific condition
3 interventional trials matched this specific condition name; 2 currently recruiting in our sample.
Data as of 27 July 2026
3 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 85.1th percentile).
low confidence · 85.1th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
3 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06671639·RECRUITING·Stanford Program to Accelerate Robotic Children's Surgery
Conditions: Sleeve Gastrectomy · Cholecystectomy · Splenectomy · Hysterectomy·Matched via name phrase
- NCT07057258·ENROLLING BY INVITATION·Injection Versus Suture Repair of Laryngeal Clefts
Conditions: Laryngeal Cleft · Dysphagia·Matched via name phrase
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Laryngotracheoesophageal cleft" OR "Laryngo-tracheo-esophageal cleft" OR "Laryngo-tracheo-esophageal diastema" OR "Larnygeotracheoesophageal cleft" OR "congenital cleft larynx" OR "laryngeal cleft" OR "tracheal cleft"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Laryngotracheoesophageal cleft" OR "Laryngo-tracheo-esophageal cleft" OR "Laryngo-tracheo-esophageal diastema" OR "Larnygeotracheoesophageal cleft" OR "congenital cleft larynx" OR "laryngeal cleft" OR "tracheal cleft"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 3 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: LC; LTEC
Confidence reasoning
- Preferred label is multi-word and distinctive
- 2 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (16903) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity
Ingested 2026-07-26T18:43:06.448Z