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ORPHA:199323

Endophthalmitis

low confidenceDisorder

Publications

30,113

Trials

33

Interventional, condition-specific

Researchers

1,047

Distinct authors in sample

Gene link

—

Readiness

5/6

Stages with a signal

Clinical definition (Orphanet)

A rare ophthalmic disorder characterized by inflammation involving the vitreous and/or aqueous humors, usually due to bacterial or fungal infection. It may arise endogenously from hematogenous spread of the infectious agent, or exogenously after direct inoculation, and can take an acute or chronic course. Clinical signs and symptoms include vitritis, hypopyon, reduced or blurred vision, red eye, pain, and lid swelling. The condition may be complicated by panophthalmitis, corneal infiltration and perforation, affection of orbital structures, and phthisis bulbi.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

5/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    30,113 matched papers (16,091 in last 10 years) Source

  3. Phenotype characterisedPresent

    32 HPO annotations (e.g. Reduced visual acuity; Corneal perforation; Deep anterior chamber) Source

  4. Animal modelPresent

    3 genotype models (Rattus norvegicus) Source

  5. Orphan designationPresent

    3 FDA designations (3 FDA orphan-indication approvals) — e.g. povidone iodine Source

  6. Interventional trialPresent

    33 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

32

Associated phenotypes · MONDO:0016047

  • Reduced visual acuity
  • Corneal perforation
  • Deep anterior chamber
  • Blurred vision
  • Herpetiform corneal ulceration

Showing 5 of 32 — open Monarch for the full list.

Animal models (Monarch / Alliance)

3

Model associations linked to this Mondo ID

  • DA·RGD:60997·Rattus norvegicus
  • AO·RGD:70429·Rattus norvegicus
  • LEW·RGD:60999·Rattus norvegicus

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

3

Designations · 3 with FDA orphan-indication approval

  • FDA povidone iodineEndophthalmitis · 2018-11-30 · Not FDA Approved for Orphan Indication
  • FDA povidone iodineEndophthalmitis · 2017-11-27 · Not FDA Approved for Orphan Indication
  • FDA vancomycinEndophthalmitis · 2012-12-27 · Not FDA Approved for Orphan Indication

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

4

Drugs / clinical candidates · MONDO_0016047

CTD chemicals (MyDisease.info)

13 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Amikacin · therapeutic
  • Azathioprine · therapeutic
  • Cefuroxime · therapeutic
  • Cyclophosphamide · therapeutic
  • Gentamicins · therapeutic
  • liposomal amphotericin B · therapeutic
  • Prednisolone · therapeutic
  • Tobramycin · therapeutic
  • Vancomycin · therapeutic
  • Alendronate · marker/mechanism
  • Cocaine · marker/mechanism
  • Methamphetamine · marker/mechanism

MyDisease.info · MONDO:0016047

Literature

Is anyone studying this?

30,113

30,113 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

30,113 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

16,091 in the last 10 years · low confidence

Phrase hits: 30,113 · MeSH hits: 745

Open Europe PMC search

Who's working on it?

1,047

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Flynn HW Jr10 papers · 2026

    Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL, USA.

    Papers in Europe PMC
  2. 02
    Zhang Y7 papers · 2026

    Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

    Papers in Europe PMC
  3. 03
    Bari A6 papers · 2026
    Papers in Europe PMC
  4. 04
    Miller D5 papers · 2026

    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 Northwest 17th Street, Miami, FL, 33136, USA.

    Papers in Europe PMC
  5. 05
    Rohowetz LJ5 papers · 2026

    Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL, USA.

    Papers in Europe PMC
  6. 06
    Zhang C5 papers · 2026

    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, United States.

    Papers in Europe PMC
  7. 07
    Wu H4 papers · 2026

    Department of Ophthalmology, the Second Hospital of Jilin University, Changchun, Jilin, China.

    Papers in Europe PMC
  8. 08
    Yannuzzi NA4 papers · 2026

    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller, School of Medicine, 900 NW 17th Street, Miami, FL, 33136, USA.

    Papers in Europe PMC
  9. 09
    Zhang X4 papers · 2026

    Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

    Papers in Europe PMC
  10. 10
    Zhou Y4 papers · 2026

    Department of Ophthalmology, University of Florida, Gainesville, FL, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

33

interventional trials for this specific condition

33 interventional trials matched this specific condition name; 1 currently recruiting in our sample.

Data as of 11 September 2026

33 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 96.2th percentile).

low confidence · 96.2th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

33 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

20 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 30 · after dedupe 30 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 30 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (30)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Endophthalmitis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Endophthalmitis"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Endophthalmitis

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Endophthalmitis"

Interventional trials matched via: both (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 33 interventional · 20 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (30113) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-27T09:13:18.588Z