ORPHA:1945
Self-limited epilepsy with centrotemporal spikes
Also known as: BECRS · BECTS · BRE · Benign epilepsy of childhood with centrotemporal spikes · Benign familial epilepsy of childhood with rolandic spikes · Benign rolandic epilepsy · Centrotemporal epilepsy · Rolandic epilepsy · SeLECTS
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Clinical definition (Orphanet)
A rare focal childhood characterized by involving unilateral facial sensory-motor symptoms, with electroencephalogram (EEG) showing sharp biphasic waves over the rolandic region. It is an age-related , with excellent outcome. Self-Limited with CentroTemporal Spikes (SeLECTS) was formerly known as benign Rolandic or benign with centrotemporal spikes.
How rare: How common this is has not been clearly measured.
Is anyone studying this?
127,729
127,729 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
127,729 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
85,746 in the last 10 years · low confidence
Is a treatment being tested?
9
trials for this specific condition
9 interventional trials matched this specific condition name; 1 currently recruiting in our sample.
Data as of 26 July 2026
9 interventional trials — more than 59.2% of diseases in the trials denominator have none at all (151 of 255; this disease is at the 85.9th percentile).
low confidence · 85.9th percentile (trials denominator)
Do we know what causes it?
Possibly — only limited evidence so far for BRWD3.
GenCC classification: Limited.
Who's working on it?
910
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Li Y22 papers · 2026
Department of Neurology, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Papers in Europe PMC - 02Wang X18 papers · 2026
Department of Neurology, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Papers in Europe PMC - 03Wang Y14 papers · 2026
Department of Neurology, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Papers in Europe PMC - 04Wang J11 papers · 2026
School of Cybersecurity (Xin Gu Industrial College), Chengdu University of Information Technology, No. 24, Section 1, Xuefu Road, Chengdu Southwest Airport Economic Development Zone, Chengdu 610225, P.R. China.
Papers in Europe PMC - 05Baumer FM10 papers · 2026
Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA. Electronic address: fbaumer@stanford.edu.
Papers in Europe PMC - 06Liu H10 papers · 2025
Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, China. Electronic address: zmcliuh@163.com.
Papers in Europe PMC - 07Zhang J9 papers · 2026
Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
Papers in Europe PMC - 08Chen Q8 papers · 2026
MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu, P. R. China.
Papers in Europe PMC - 09He Z8 papers · 2026
Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA. Electronic address: zihuai@stanford.edu.
Papers in Europe PMC - 10Li X7 papers · 2026
Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
9 interventional trials matched after quoted-phrase search and title/condition post-filter.
Observational and natural-history studies
9 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
Recruiting or not-yet-recruiting
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Self-limited epilepsy with centrotemporal spikes" OR "BECRS" OR "BECTS" OR "Benign epilepsy of childhood with centrotemporal spikes" OR "Benign familial epilepsy of childhood with rolandic spikes" OR "Benign rolandic epilepsy" OR "Centrotemporal epilepsy" OR "Rolandic epilepsy" OR "SeLECTS" OR "BCECTS" OR "benign Rolandic epilepsy (BRE)" OR "benign Rolandic epilepsy of childhood (BREC)" OR "benign childhood epilepsy with centrotemporal spikes" OR "benign epilepsy with centrotemporal spikes" OR "centralopathic epilepsy" OR "centrotemporal epilepsy, isolated cases" OR "childhood epilepsy with centrotemporal spikes" OR "temporal-central focal epilepsy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Self-limited epilepsy with centrotemporal spikes" OR "BECRS" OR "BECTS" OR "Benign epilepsy of childhood with centrotemporal spikes" OR "Benign epilepsy of the childhood with centrotemporal spikes" OR "Benign familial epilepsy of childhood with rolandic spikes" OR "Benign familial epilepsy of the childhood with rolandic spikes" OR "Benign rolandic epilepsy" OR "Centrotemporal epilepsy" OR "Rolandic epilepsy" OR "SeLECTS" OR "BCECTS" OR "benign Rolandic epilepsy (BRE)" OR "benign Rolandic epilepsy of childhood (BREC)" OR "benign Rolandic epilepsy of the childhood (BREC)" OR "benign childhood epilepsy with centrotemporal spikes" OR "benign epilepsy with centrotemporal spikes" OR "centralopathic epilepsy" OR "centrotemporal epilepsy, isolated cases" OR "childhood epilepsy with centrotemporal spikes" OR "temporal-central focal epilepsy" OR "BRWD3" OR "familial partial epilepsy" OR "childhood-onset self-limited focal epilepsy syndrome"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 9 interventional · 9 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): OMIM:117100 UMLS:C0376532 NCIT:C116538
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: BRE
Confidence reasoning
- Preferred label is multi-word and distinctive
- 1 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (127729) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity