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ORPHA:1945

Self-limited epilepsy with centrotemporal spikes

low confidenceDisorder

Also known as: BECRS · BECTS · BRE · Benign epilepsy of childhood with centrotemporal spikes · Benign familial epilepsy of childhood with rolandic spikes · Benign rolandic epilepsy · Centrotemporal epilepsy · Rolandic epilepsy · SeLECTS

Publications

128,165

Trials

9

Interventional, condition-specific

Researchers

910

Distinct authors in sample

Gene link

BRWD3

Limited

Readiness

5/6

Stages with a signal

Clinical definition (Orphanet)

A rare focal childhood characterized by involving unilateral facial sensory-motor symptoms, with electroencephalogram (EEG) showing sharp biphasic waves over the rolandic region. It is an age-related , with excellent outcome. Self-Limited with CentroTemporal Spikes (SeLECTS) was formerly known as benign Rolandic or benign with centrotemporal spikes.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (13)

BCECTS · benign Rolandic epilepsy · benign Rolandic epilepsy (BRE) · benign Rolandic epilepsy of childhood (BREC) · benign childhood epilepsy with centrotemporal spikes · benign epilepsy of childhood with centrotemporal spikes · benign epilepsy with centrotemporal spikes · benign familial epilepsy of childhood with rolandic spikes · centralopathic epilepsy · centrotemporal epilepsy · centrotemporal epilepsy, isolated cases · childhood epilepsy with centrotemporal spikes · temporal-central focal epilepsy

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

5/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedPresent

    Limited — BRWD3

  2. LiteraturePresent

    128,165 matched papers (86,060 in last 10 years) Source

  3. Phenotype characterisedPresent

    25 HPO annotations (e.g. Bilateral tonic-clonic seizure with focal onset; Focal-onset seizure; Speech articulation difficulties) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPresent

    1 FDA designation (1 FDA orphan-indication approval) — e.g. sulthiame Source

  6. Interventional trialPresent

    9 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Possibly — only limited evidence so far for BRWD3.

GenCC classification: Limited.

Phenotypes (Monarch / HPO)

25

Associated phenotypes · MONDO:0007295

  • Bilateral tonic-clonic seizure with focal onset
  • Focal-onset seizure
  • Speech articulation difficulties
  • Sleep apnea
  • Laryngospasm

Showing 5 of 25 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-27

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · 1 with FDA orphan-indication approval

  • FDA sulthiamerolandic epilepsy Benign Epilepsy Of Childhood With Centrotemporal Spikes · 2013-07-25 · Not FDA Approved for Orphan Indication

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

4 associated chemicals · 74 pathways. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Carbamazepine · therapeutic
  • Clobazam · therapeutic
  • Topiramate · therapeutic
  • Valproic Acid · therapeutic

Pathways: Ras signaling pathway; Rap1 signaling pathway; Calcium signaling pathway; cAMP signaling pathway; Neuroactive ligand-receptor interaction; Circadian entrainment; Long-term potentiation; Glutamatergic synapse

MyDisease.info · MONDO:0007295

Literature

Is anyone studying this?

128,165

128,165 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

128,165 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

86,060 in the last 10 years · low confidence

Phrase hits: 127,729 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

910

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li Y22 papers · 2026

    Department of Neurology, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.

    Papers in Europe PMC
  2. 02
    Wang X18 papers · 2026

    Department of Neurology, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.

    Papers in Europe PMC
  3. 03
    Wang Y14 papers · 2026

    Department of Neurology, The Affiliated Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.

    Papers in Europe PMC
  4. 04
    Wang J11 papers · 2026

    School of Cybersecurity (Xin Gu Industrial College), Chengdu University of Information Technology, No. 24, Section 1, Xuefu Road, Chengdu Southwest Airport Economic Development Zone, Chengdu 610225, P.R. China.

    Papers in Europe PMC
  5. 05
    Baumer FM10 papers · 2026

    Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA. Electronic address: fbaumer@stanford.edu.

    Papers in Europe PMC
  6. 06
    Liu H10 papers · 2025

    Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, China. Electronic address: zmcliuh@163.com.

    Papers in Europe PMC
  7. 07
    Zhang J9 papers · 2026

    Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

    Papers in Europe PMC
  8. 08
    Chen Q8 papers · 2026

    MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu, P. R. China.

    Papers in Europe PMC
  9. 09
    He Z8 papers · 2026

    Department of Neurology, Stanford University School of Medicine, Palo Alto, CA, USA. Electronic address: zihuai@stanford.edu.

    Papers in Europe PMC
  10. 10
    Li X7 papers · 2026

    Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

9

interventional trials for this specific condition

9 interventional trials matched this specific condition name; 1 currently recruiting in our sample.

Data as of 9 September 2026 · last trial check 28 July 2026

9 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 92th percentile).

low confidence · 92th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

9 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

9 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 1 · after dedupe 1 · already on CT.gov 0 · kept 1 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-27

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Self-limited epilepsy with centrotemporal spikes — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

("Self-limited epilepsy with centrotemporal spikes" OR "BECRS" OR "BECTS" OR "Benign epilepsy of childhood with centrotemporal spikes" OR "Benign epilepsy of the childhood with centrotemporal spikes" OR "Benign familial epilepsy of childhood with rolandic spikes" OR "Benign familial epilepsy of the childhood with rolandic spikes" OR "Benign rolandic epilepsy" OR "Centrotemporal epilepsy" OR "Rolandic epilepsy" OR "SeLECTS" OR "BCECTS" OR "benign Rolandic epilepsy (BRE)" OR "benign Rolandic epilepsy of childhood (BREC)" OR "benign Rolandic epilepsy of the childhood (BREC)" OR "benign childhood epilepsy with centrotemporal spikes" OR "benign epilepsy with centrotemporal spikes" OR "centralopathic epilepsy" OR "centrotemporal epilepsy, isolated cases" OR "childhood epilepsy with centrotemporal spikes" OR "temporal-central focal epilepsy") OR ("BRWD3" OR "BRWD3 syndrome" OR "BRWD3-related")

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Self-limited epilepsy with centrotemporal spikes" OR "BECRS" OR "BECTS" OR "Benign epilepsy of childhood with centrotemporal spikes" OR "Benign epilepsy of the childhood with centrotemporal spikes" OR "Benign familial epilepsy of childhood with rolandic spikes" OR "Benign familial epilepsy of the childhood with rolandic spikes" OR "Benign rolandic epilepsy" OR "Centrotemporal epilepsy" OR "Rolandic epilepsy" OR "SeLECTS" OR "BCECTS" OR "benign Rolandic epilepsy (BRE)" OR "benign Rolandic epilepsy of childhood (BREC)" OR "benign Rolandic epilepsy of the childhood (BREC)" OR "benign childhood epilepsy with centrotemporal spikes" OR "benign epilepsy with centrotemporal spikes" OR "centralopathic epilepsy" OR "centrotemporal epilepsy, isolated cases" OR "childhood epilepsy with centrotemporal spikes" OR "temporal-central focal epilepsy"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 9 interventional · 9 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: BRE

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • 1 synonym(s) dropped by stoplist (may under-count)
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (128165) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T02:05:23.824Z