ORPHA:178475
Wound botulism
Also known as: Cutaneous infectious botulism · Cutaneous toxin-mediated botulism · Inoculation botulism · Skin infectious botulism · Skin toxin-mediated botulism
Query health: suspect — Only one of 2 strategies returned hits (phrase).
Publications
568
81.9th percentile
Trials
0
Interventional, condition-specific
Researchers
961
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
Wound botulism is a rare infectious form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs), produced after infection of wounds by Clostridium botulinum.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0015803
- UMLS:C1306794
- NCIT:C128342
Additional Mondo synonyms (5)
cutaneous infectious botulism · cutaneous toxin-mediated botulism · inoculation botulism · skin infectious botulism · skin toxin-mediated botulism
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
568 matched papers (250 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 17 for broader category botulism
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
568
568 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
568 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
250 in the last 10 years · high confidence · 81.9th percentile (publications denominator)
Phrase hits: 568 · MeSH hits: 0
Who's working on it?
961
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Anniballi F6 papers · 2022
National Reference Centre for Botulism (NRCB), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy. fabrizio.anniballi@iss.it.
Papers in Europe PMC - 02Popoff MR5 papers · 2022
Institut Pasteur, Université de Paris, Unité Toxines Bactériennes, F-75015 Paris, France.
Papers in Europe PMC - 03Austin JW4 papers · 2023
Botulism Reference Service for Canada, Health Canada, Ottawa, ON.
Papers in Europe PMC - 04Chatham-Stephens K4 papers · 2021
National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.
Papers in Europe PMC - 05Lúquez C4 papers · 2021
1 Centers for Disease Control and Prevention, Enteric Diseases Laboratory Branch, National Botulism and Enteric Toxins Team, Atlanta, Georgia.
Papers in Europe PMC - 06Rasetti-Escargueil C4 papers · 2024
Institut Pasteur, Université de Paris, Unité Toxines Bactériennes, F-75015 Paris, France.
Papers in Europe PMC - 07Smith TJ4 papers · 2026
Pathogen and Microbiome Institute, Northern Arizona University.
Papers in Europe PMC - 08Xu X4 papers · 2025
State Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing, China.
Papers in Europe PMC - 09Alam SI3 papers · 2021
Biotechnology Division, Defence Research & Development Establishment, Gwalior, 474 002, India.
Papers in Europe PMC - 10Amar C3 papers · 2020
3 Consultant in Public Health, Gastrointestinal Bacterial Reference Unit, Public Health England, UK.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present). 17 trials are registered for botulism, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
17 interventional trials matched botulism, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: botulism
17
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Recruiting under the broader category
- NCT06580236·NOT YET RECRUITING·Study of the Drug B11-FC (Botulism Treatment)
Conditions: Botulism·Matched via name phrase
- NCT02051062·ENROLLING BY INVITATION·BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients
Conditions: Botulism·Matched via name phrase
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Wound botulism" OR "Cutaneous infectious botulism" OR "Cutaneous toxin-mediated botulism" OR "Inoculation botulism" OR "Skin infectious botulism" OR "Skin toxin-mediated botulism"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Wound botulism" OR "Cutaneous infectious botulism" OR "Cutaneous toxin-mediated botulism" OR "Inoculation botulism" OR "Skin infectious botulism" OR "Skin toxin-mediated botulism" OR "toxin-mediated infectious botulism"
Recall-expansion terms: toxin-mediated infectious botulism
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"botulism"
Query health: suspect — strategies attempted: phrase, recall-expansion; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T08:52:52.393Z