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ORPHA:173

Cholera

low confidenceDisorder

Publications

119,270

Trials

68

Interventional, condition-specific

Researchers

1,313

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

Cholera is an infectious disease, caused by intestinal infection with Vibrio cholerae, characterized by massive watery diarrhea and severe dehydration that can lead to shock and death if left untreated.

How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

Vibrio cholerae caused disease or disorder · Vibrio cholerae disease or disorder · Vibrio cholerae infectious disease · cholera due to Vibrio cholerae

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    119,270 matched papers (36,472 in last 10 years) Source

  3. Phenotype characterisedPresent

    33 HPO annotations (e.g. Tachycardia; Acidosis; Dehydration) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    68 matched on ClinicalTrials.gov (11 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

33

Associated phenotypes · MONDO:0015766

  • Tachycardia
  • Acidosis
  • Dehydration
  • Vomiting
  • Hypotension

Showing 5 of 33 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

1 associated chemical. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • cholera vaccine CVD 103-HgR · therapeutic

MyDisease.info · MONDO:0015766

Literature

Is anyone studying this?

119,270

119,270 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

119,270 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

36,472 in the last 10 years · low confidence

Phrase hits: 119,270 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,313

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Qadri F8 papers · 2026

    Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh. fqadri@icddrb.org.

    Papers in Europe PMC
  2. 02
    Khan AI7 papers · 2026

    Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

    Papers in Europe PMC
  3. 03
    Azman AS6 papers · 2026

    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.

    Papers in Europe PMC
  4. 04
    Islam MT6 papers · 2026

    International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Bangladesh.

    Papers in Europe PMC
  5. 05
    Chilengi R5 papers · 2026

    Zambia National Public Health Institute, Stand 1186, Corner of Chaholi and Addis Ababa Roads, Rhodes Park, Lusaka 10101, Zambia.

    Papers in Europe PMC
  6. 06
    Sack DA5 papers · 2026

    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

    Papers in Europe PMC
  7. 07
    ALZubaidy AB4 papers · 2026
    Papers in Europe PMC
  8. 08
    Bhuiyan TR4 papers · 2026

    Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

    Papers in Europe PMC
  9. 09
    Cholera R4 papers · 2026

    North Carolina Integrated Care for Kids (S Allin, A Saunders, E Wertman, C Swanson, and R Cholera), Durham, NC; Duke-Margolis Institute for Health Policy (C Swanson and R Cholera), Durham, NC; Department of Pediatrics (RJ Chung and R Cholera), Duke University School of Medicine, Durham, NC; Department of Population Health Sciences (R Cholera), Duke University School of Medicine, Durham, NC. Electronic address: rushina.cholera@duke.edu.

    Papers in Europe PMC
  10. 10
    Dedy HBH4 papers · 2026
    Papers in Europe PMC

Clinical research

Is a treatment being tested?

68

interventional trials for this specific condition

68 interventional trials matched this specific condition name; 11 currently recruiting in our sample.

Data as of 11 September 2026

68 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 98th percentile).

low confidence · 98th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

68 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

8 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 17 · after dedupe 17 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 17 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (17)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Cholera — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

("Cholera" OR "Vibrio cholerae infectious disease" OR "cholera due to Vibrio cholerae")

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Cholera" OR "Vibrio cholerae infectious disease" OR "cholera due to Vibrio cholerae"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 68 interventional · 8 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Synonyms dropped by stoplist: Vibrio cholerae caused disease or disorder; Vibrio cholerae disease or disorder

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (119270) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity

Ingested 2026-07-26T12:44:56.099Z