ORPHA:171684
Idiopathic bilateral vestibulopathy
Publications
57
43.2th percentile
Trials
0
Interventional, condition-specific
Researchers
258
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
bilateral vestibulopathy is a rare otorhinolaryngologic disease characterized by dysfunction of both peripheral labyrinths or of the eighth cranial nerves, which presents with persistent unsteadiness of gait (particularly in darkness, during eye closure or under impaired visual conditions, or when standing/walking on uneven, soft or wobbly ground) and oscillopsia associated with head movements. The disease may be , presenting no episodes of vertigo, or sequential, presenting recurrent episodes of vertigo.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0015743
- UMLS:C4545229
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
57 matched papers (35 in last 10 years) Source
- Phenotype characterisedPresent
11 HPO annotations (e.g. Abnormal vestibulo-spinal reflex; Memory impairment; Diminished ability to concentrate) Source
- Animal modelNot found
No Alliance genotype “model of” associations via Monarch for these Mondo IDs
- Orphan designationNot found
No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
11
Associated phenotypes · MONDO:0015743
- Abnormal vestibulo-spinal reflex
- Memory impairment
- Diminished ability to concentrate
- Pathological sadness
- Anxiety
Showing 5 of 11 — open Monarch for the full list.
Animal models (Monarch / Alliance)
None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.
Monarch fetch 2026-07-29
Therapies
Designations, candidates, and chemicals
FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.
Orphan designation (FDA · EMA)
No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.
Open Targets candidates
No drugs or clinical candidates returned for this Mondo ID on Open Targets.
CTD chemicals (MyDisease.info)
No CTD chemical associations returned for this Mondo ID.
Literature
Is anyone studying this?
57
57 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.
57 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).
35 in the last 10 years · high confidence · 43.2th percentile (publications denominator)
Phrase hits: 57 · MeSH hits: 0
Who's working on it?
258
Distinct author names in 57 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Iwasaki S7 papers · 2022
Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan.
Papers in Europe PMC - 02Fujimoto C6 papers · 2020
Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan.
Papers in Europe PMC - 03Murofushi T6 papers · 2019
Department of Otolaryngology, Teikyo University School of Medicine, Mizonokuchi Hospital Kawasaki, Japan.
Papers in Europe PMC - 04Strupp M5 papers · 2017
Department of Neurology and German Center for Vertigo and Balance Disorders (IFB), Institute for Clinical Neurosciences, Ludwig-Maximilians University of Munich, Klinikum Großhadern, Germany. Michael.Strupp@med.uni-muenchen.de
Papers in Europe PMC - 05Yamasoba T5 papers · 2025
Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan.
Papers in Europe PMC - 06Brandt T4 papers · 2013
Department of Neurology with Friedrich-Baur-Institute, Ludwig-Maximilians-University, Klinikum Grosshadern, Munich, Germany.
Papers in Europe PMC - 07Kamogashira T4 papers · 2025
Department of Otolaryngology and Head and Neck Surgery, University of Tokyo, Tokyo, Japan.
Papers in Europe PMC - 08Dieterich M3 papers · 2013Papers in Europe PMC
- 09Lewis RF3 papers · 2023
Department of Otology and Laryngology and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02114 Richard_lewis@meei.harvard.edu.
Papers in Europe PMC - 10Arbusow V2 papers · 1999
Department of Neurology, University of Munich, Grosshadern Medical Centre, Germany.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial.
Data as of 11 September 2026 · last trial check 11 September 2026
No matched interventional trials. This is true for 77.2% of diseases in the trials denominator (5501 of 7126). Here are the researchers publishing on it.
high confidence · 38.6th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Other registries (secondary)
Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.
raw 0 · after dedupe 0 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 0 · dropped 0 · fetched 2026-07-30
Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri
No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).
Where to find support
Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.
Orphanet entry for Idiopathic bilateral vestibulopathy — check Associations / patient organisations on that page.
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Idiopathic bilateral vestibulopathy"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Idiopathic bilateral vestibulopathy"
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T08:41:24.475Z