ORPHA:1686
Cardiac diverticulum
Publications
107
50.5th percentile
Trials
0
Interventional, condition-specific
Researchers
495
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
cardiac diverticulum (CCD) is a very rare characterized by a muscular appendix emerging from the left ventricular apex, rarely from the right ventricle or from both chambers, with clinical manifestations ranging from asymptomatic to life-threatening hemodynamic collapse.
How rare: How common this is has not been clearly measured.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0015677
- UMLS:C0546315
Additional Mondo synonyms (1)
cardiac diverticulum (disease)
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
107 matched papers (42 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
107
107 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
107 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
42 in the last 10 years · high confidence · 50.5th percentile (publications denominator)
Phrase hits: 107 · MeSH hits: 0
Who's working on it?
495
Distinct author names in 107 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Zhang Y3 papers · 2025
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China.
Papers in Europe PMC - 02Arias-Díaz A2 papers · 2021
Unidad de Cuidados Intensivos Pediátricos Doña Pilar. Cartagena, Colombia. Unidad de Cuidados Intensivos Pediátricos Doña Pilar
Papers in Europe PMC - 03Carvalho JS2 papers · 2005
Brompton Fetal Cardiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. j.carvalho@rbh.nthames.nhs.uk
Papers in Europe PMC - 04Chen P2 papers · 2024
Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
Papers in Europe PMC - 05Chen Y2 papers · 2022
Shanghai Synyi Medical Technology Co., Ltd. 201203 Shanghai, China.
Papers in Europe PMC - 06de Leeuw FE2 papers · 2011Papers in Europe PMC
- 07Ding B2 papers · 2025
Department of Second Ward of Thoracic Surgery, The First Affiliated Hospital, Shandong Second Medical University.
Papers in Europe PMC - 08Du X2 papers · 2022
Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China.
Papers in Europe PMC - 09Garcia Delgado R2 papers · 2017
Prenatal Diagnosis and Fetal Therapy Unit, Department of Obstetrics and Gynecology, University Maternity Hospital of Canaries, Las Palmas, 35004 Gran Canaria, Spain.
Papers in Europe PMC - 10Garcia Hernandez JA2 papers · 2017
Prenatal Diagnosis and Fetal Therapy Unit, Department of Obstetrics and Gynecology, University Maternity Hospital of Canaries, Las Palmas, 35004 Gran Canaria, Spain.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Cardiac diverticulum" OR "cardiac diverticulum (disease)"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Cardiac diverticulum" OR "cardiac diverticulum (disease)"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T17:58:50.343Z