ORPHA:166291
Dirofilariasis
Publications
4,352
Trials
0
Interventional, condition-specific
Researchers
1,099
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Dirofilariasis is a form of filariasis, caused by the filarial nematode of the genus Dirofilaria (including Dirofilaria repens, Dirofilaria immitis), which is transmitted by mosquitoes. The disease is characterized by the presence of subcutaneous nodules (or a conjunctival form that develops slowly and that can be painless to tender), edema and erythema at the site of parasite localization, a feeling of 'crawling' under the skin, and the ''Calabar'' swelling (similar to thatin loiasis. The latter may last a few days and recurrences are possible. Common localizations of dirofilaria are head and neck, most commonly in the periorbital region, the limbs and trunk.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0015636
- MeSH:D004184
- UMLS:C0012602
Additional Mondo synonyms (3)
Dirofilaria caused disease or disorder · Dirofilaria disease or disorder · infection by Dirofilaria
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
4,352 matched papers (1,590 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
4,352
4,352 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
4,352 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
1,590 in the last 10 years · low confidence
Phrase hits: 4,352 · MeSH hits: 49
Who's working on it?
1,099
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Morchón R8 papers · 2026
Zoonotic Diseases and One Health group, IBSAL-CIETUS (Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases University of Salamanca), Faculty of Pharmacy, University of Salamanca, 37007, Salamanca, Spain. Electronic address: rmorgar@usal.es.
Papers in Europe PMC - 02Carretón E7 papers · 2026
Internal Medicine, Faculty of Veterinary Medicine, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. Electronic address: elena.carreton@ulpgc.es.
Papers in Europe PMC - 03Montoya-Alonso JA7 papers · 2026
Internal Medicine, Faculty of Veterinary Medicine, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Papers in Europe PMC - 04Otranto D7 papers · 2026
Department of Veterinary Medicine, University of Bari, Valenzano, Italy; Department of Veterinary Clinical Sciences, City University of Hong Kong, Hong Kong Special Administrative Region.
Papers in Europe PMC - 05Rodríguez-Escolar I7 papers · 2026
Zoonotic Diseases and One Health group, IBSAL-CIETUS (Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases University of Salamanca), Faculty of Pharmacy, University of Salamanca, 37007, Salamanca, Spain.
Papers in Europe PMC - 06Balmori-de la Puente A6 papers · 2026
Zoonotic Diseases and One Health Group, Faculty of Pharmacy, Centre for Environmental Studies and Rural Dynamization (CEADIR), University of Salamanca, Salamanca, Spain. a.balmori@usal.es.
Papers in Europe PMC - 07Collado-Cuadrado M6 papers · 2026
Zoonotic Diseases and One Health Group, Faculty of Pharmacy, Centre for Environmental Studies and Rural Dynamization (CEADIR), University of Salamanca, Salamanca, Spain.
Papers in Europe PMC - 08
- 09Gabrielli S5 papers · 2026
Department of Public Health and Infectious diseases, Sapienza University of Rome, Rome, Italy. Electronic address: simona.gabrielli@uniroma1.it.
Papers in Europe PMC - 10Gasser RB5 papers · 2025
Department of Veterinary Biosciences, Melbourne Veterinary School, Faculty of Science, The University of Melbourne, Parkville, Vic, Australia.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Dirofilariasis" OR "infection by Dirofilaria"
MeSH descriptor terms unioned into the query: Dirofilariasis
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Dirofilariasis" OR "infection by Dirofilaria"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: Dirofilaria caused disease or disorder; Dirofilaria disease or disorder
Confidence reasoning
- Preferred label is short or not clearly distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
- Publication count (4352) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity
Ingested 2026-07-27T08:23:05.310Z