ORPHA:163525
Subacute cutaneous lupus erythematosus
Clinical definition (Orphanet)
A form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. This disorder is associated with anti-Ro/SSA antibodies and can be drug-induced.
How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.
Is anyone studying this?
1,647
1,647 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=183) is 38.
1,647 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 38 (publications denominator n=183).
856 in the last 10 years · high confidence · 93.7th percentile (publications denominator)
Is a treatment being tested?
9
trials for this specific condition
9 interventional trials matched this specific condition name; 2 currently recruiting in our sample. 39 trials are registered for cutaneous lupus erythematosus, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 26 July 2026
39
trials for cutaneous lupus erythematosus, the broader category this belongs to
Trials registered for a broader category may or may not enrol people with this specific subtype — eligibility criteria vary, and the trial record often doesn't say. Worth raising with a clinician. How we count trials.
9 interventional trials — more than 59.2% of diseases in the trials denominator have none at all (151 of 255; this disease is at the 85.9th percentile).
high confidence · 85.9th percentile (trials denominator)
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Who's working on it?
925
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.
- 01Werth VP6 papers · 2026
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania. Electronic address: werth@pennmedicine.upenn.edu.
Papers in Europe PMC - 02Wang C4 papers · 2025
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, China.
Papers in Europe PMC - 03Hidvégi B3 papers · 2026
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Papers in Europe PMC - 04Király Z3 papers · 2026
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
Papers in Europe PMC - 05Kleitsch J3 papers · 2025
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania.
Papers in Europe PMC - 06Lu Q3 papers · 2026
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China qianlu5860@pumcderm.cams.cn.
Papers in Europe PMC - 07Ma S3 papers · 2025
Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Papers in Europe PMC - 08Mohta A3 papers · 2023
Departments of Preventive and Social Medicine, Sardar Patel Medical College, Bikaner, Rajasthan, India.
Papers in Europe PMC - 09Motaparthi K3 papers · 2025
Dermatology, University of Florida, Gainesville, USA.
Papers in Europe PMC - 10Wenzel J3 papers · 2026
Department for Dermatology and Allergy, Center for Skin Diseases, University Hospital Bonn, Bonn, Germany.
Papers in Europe PMC
Recruiting interventional trials
Trials testing a treatment from the matched ClinicalTrials.gov set
9 interventional trials matched after quoted-phrase search and title/condition post-filter.
- NCT06044337·A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
- NCT06875960·A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored below but are not added to the query string.
"Subacute cutaneous lupus erythematosus"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Subacute cutaneous lupus erythematosus"
Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).
Study-type breakdown: 9 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Cross-references (from Mondo): UMLS:C0024140 NCIT:C117111
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus