RARE DISEASERESEARCH ATLAS
Open navigation menu

ORPHA:1467

Cogan syndrome

medium confidenceDisorder

Publications

729

88.3th percentile

Trials

1

Interventional, condition-specific

Researchers

1,033

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare inflammatory/autoimmune disorder of unknown origin characterized by interstitial keratitis (IK) and audiovestibular dysfunctions.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    729 matched papers (410 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

729

729 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

729 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

410 in the last 10 years · medium confidence · 88.3th percentile (publications denominator)

Phrase hits: 729 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,033

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Mekinian A4 papers · 2025

    AP-HP, Hôpital Saint-Antoine, service de médecine interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC University, Paris 06, F-75012, Paris, France. Electronic address: arsene.mekinian@aphp.fr.

    Papers in Europe PMC
  2. 02
    Bogdanos DP3 papers · 2026

    Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis campus, Biopolis, Larissa, Greece.

    Papers in Europe PMC
  3. 03
    Choi JY3 papers · 2025

    From the Department of Neurology (S.-U.L.), Korea University Anam Hospital; Department of Neurology (S.-U.L., J.-S.K., J.-Y.C.), Dizziness Center, Clinical Neuroscience Center, and Department of Neurology (J.-S.K., J.-Y.C.), Department of Ophthalmology (J.Y.H.), and Department of Otolaryngology-Head and Neck Surgery (J.-J.S.), Seoul National University College of Medicine, Division of Rheumatology, Department of Internal Medicine (Y.-J.H.), and Research Administration Team (H.-J.K.), Seoul National University Bundang Hospital, Seongnam, South Korea; and Department of Neurology (X.Y.), Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Peking, China.

    Papers in Europe PMC
  4. 04
    Goulis DG3 papers · 2026

    Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.

    Papers in Europe PMC
  5. 05
    Grammatikopoulou MG3 papers · 2026

    Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis campus, Biopolis, Larissa, Greece. mgrammat@uth.gr.

    Papers in Europe PMC
  6. 06
    Katsiari CG3 papers · 2026

    Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis campus, Biopolis, Larissa, Greece.

    Papers in Europe PMC
  7. 07
    Kim JS3 papers · 2025

    From the Department of Neurology (S.-U.L.), Korea University Anam Hospital; Department of Neurology (S.-U.L., J.-S.K., J.-Y.C.), Dizziness Center, Clinical Neuroscience Center, and Department of Neurology (J.-S.K., J.-Y.C.), Department of Ophthalmology (J.Y.H.), and Department of Otolaryngology-Head and Neck Surgery (J.-J.S.), Seoul National University College of Medicine, Division of Rheumatology, Department of Internal Medicine (Y.-J.H.), and Research Administration Team (H.-J.K.), Seoul National University Bundang Hospital, Seongnam, South Korea; and Department of Neurology (X.Y.), Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Peking, China. jisookim@snu.ac.kr.

    Papers in Europe PMC
  8. 08
    Kontouli KM3 papers · 2026

    Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.

    Papers in Europe PMC
  9. 09
    Lee SU3 papers · 2025

    From the Department of Neurology (S.-U.L.), Korea University Anam Hospital; Department of Neurology (S.-U.L., J.-S.K., J.-Y.C.), Dizziness Center, Clinical Neuroscience Center, and Department of Neurology (J.-S.K., J.-Y.C.), Department of Ophthalmology (J.Y.H.), and Department of Otolaryngology-Head and Neck Surgery (J.-J.S.), Seoul National University College of Medicine, Division of Rheumatology, Department of Internal Medicine (Y.-J.H.), and Research Administration Team (H.-J.K.), Seoul National University Bundang Hospital, Seongnam, South Korea; and Department of Neurology (X.Y.), Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Peking, China.

    Papers in Europe PMC
  10. 10
    Pardali EC3 papers · 2026

    Unit of Immunonutrition and Clinical Nutrition, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis campus, Biopolis, Larissa, Greece.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting.

Data as of 27 July 2026

1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).

medium confidence · 76.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Cogan syndrome"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Cogan syndrome"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T17:29:05.468Z