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ORPHA:146

Differentiated thyroid carcinoma

low confidenceDisorder

Also known as: Papillary or follicular thyroid carcinoma · Well-differentiated thyroid carcinoma

Publications

19,713

Trials

132

Interventional, condition-specific

Researchers

1,216

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare, slow-growing, epithelial thyroid carcinoma typically presenting as an asymptomatic thyroid mass and is classed as either papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) or Hurthle cell thyroid cancer (HCTC).

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (11)

differentiated thyroid cancer · differentiated thyroid carcinoma · differentiated thyroid gland cancer · differentiated thyroid gland carcinoma · papillary or follicular thyroid carcinoma · thyroid gland differentiated carcinoma · thyroid gland well differentiated carcinoma · well differentiated thyroid carcinoma · well differentiated thyroid gland carcinoma · well-differentiated thyroid cancer · well-differentiated thyroid carcinoma

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    19,713 matched papers (12,317 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    132 matched on ClinicalTrials.gov (35 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

19,713

19,713 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

19,713 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

12,317 in the last 10 years · low confidence

Phrase hits: 19,713 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,216

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang X5 papers · 2026

    Department of Ultrasound, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.

    Papers in Europe PMC
  2. 02
    Li J4 papers · 2026

    Division of Thyroid Surgery, The China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, Jilin Province, China.

    Papers in Europe PMC
  3. 03
    Wang J4 papers · 2026

    Department of Nuclear Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

    Papers in Europe PMC
  4. 04
    Wang Z4 papers · 2026

    Department of Head and Neck Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Electronic address: zhuoyingwang@hotmail.com.

    Papers in Europe PMC
  5. 05
    Zhang Y4 papers · 2026

    Department of Nuclear Medicine, The Third Bethune Hospital of Jilin University, Changchun, 130021, Jilin, China.

    Papers in Europe PMC
  6. 06
    Ganly I3 papers · 2025

    Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

    Papers in Europe PMC
  7. 07
    Li C3 papers · 2026

    Division of Thyroid Surgery, The China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, Jilin Province, China.

    Papers in Europe PMC
  8. 08
    Shah JP3 papers · 2025

    Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

    Papers in Europe PMC
  9. 09
    Shaha AR3 papers · 2025

    Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

    Papers in Europe PMC
  10. 10
    Tuttle RM3 papers · 2026

    Department of Medicine, Endocrine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

132

interventional trials for this specific condition

132 interventional trials matched this specific condition name; 35 currently recruiting in our sample.

Data as of 27 July 2026

132 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 98.8th percentile).

low confidence · 98.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

132 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

41 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Differentiated thyroid carcinoma" OR "Papillary or follicular thyroid carcinoma" OR "Well-differentiated thyroid carcinoma" OR "differentiated thyroid cancer" OR "differentiated thyroid gland cancer" OR "differentiated thyroid gland carcinoma" OR "thyroid gland differentiated carcinoma" OR "thyroid gland well differentiated carcinoma" OR "well differentiated thyroid carcinoma" OR "well differentiated thyroid gland carcinoma" OR "well-differentiated thyroid cancer"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Differentiated thyroid carcinoma" OR "Papillary or follicular thyroid carcinoma" OR "Well-differentiated thyroid carcinoma" OR "differentiated thyroid cancer" OR "differentiated thyroid gland cancer" OR "differentiated thyroid gland carcinoma" OR "thyroid gland differentiated carcinoma" OR "thyroid gland well differentiated carcinoma" OR "well differentiated thyroid carcinoma" OR "well differentiated thyroid gland carcinoma" OR "well-differentiated thyroid cancer"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 132 interventional · 41 observational · 2 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus
  • Publication count (19713) is extremely high with unknown/missing prevalence — treat as possible over-matching, not proven research intensity

Ingested 2026-07-26T12:38:57.192Z