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ORPHA:142

Anaplastic thyroid carcinoma

high confidenceDisorder

Publications

10,482

98.2th percentile

Trials

48

Interventional, condition-specific

Researchers

1,182

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A disorder that represents the ultimate dedifferentiation step of thyroid tumorigenesis and is one of the most severe cancers in humans.

How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (24)

Dedifferentiated thyroid gland carcinoma · anaplastic carcinoma of the thyroid · anaplastic carcinoma of the thyroid gland · anaplastic carcinoma of thyroid · anaplastic carcinoma of thyroid gland · anaplastic thyroid cancer · anaplastic thyroid carcinoma · anaplastic thyroid gland carcinoma · metaplastic thyroid gland carcinoma · pleomorphic thyroid gland carcinoma · sarcomatoid thyroid gland carcinoma · thyroid gland carcinosarcoma · thyroid gland undifferentiated (anaplastic) carcinoma · thyroid gland undifferentiated carcinoma · undifferentiated (anaplastic) thyroid gland cancer · undifferentiated (anaplastic) thyroid gland carcinoma · undifferentiated carcinoma of the thyroid · undifferentiated carcinoma of the thyroid gland · undifferentiated carcinoma of thyroid · undifferentiated carcinoma of thyroid gland · undifferentiated thyroid carcinoma · undifferentiated thyroid gland carcinoma · undifferentiated thyroid tumor · undifferentiated thyroid tumour

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    10,482 matched papers (7,470 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    48 matched on ClinicalTrials.gov (7 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

10,482

10,482 papers — among the better-studied rare conditions, though still a fraction of common-disease literature (breast cancer: over 700,000). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

10,482 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

7,470 in the last 10 years · high confidence · 98.2th percentile (publications denominator)

Phrase hits: 10,482 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

1,182

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang Y9 papers · 2026

    Thoracic Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

    Papers in Europe PMC
  2. 02
    Wang J7 papers · 2026

    Wenzhou Medical University, Postgraduate training base of Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.

    Papers in Europe PMC
  3. 03
    Ge M6 papers · 2026

    Zhejiang Provincial Clinical Research Center For Head & Neck Cancer, Hangzhou, China.

    Papers in Europe PMC
  4. 04
    Wang X6 papers · 2026

    The Fourth Department of General Surgery, The First Hospital of Harbin, Harbin, Heilongjiang, China.

    Papers in Europe PMC
  5. 05
    Zhang Y6 papers · 2026

    Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

    Papers in Europe PMC
  6. 06
    Cabanillas ME5 papers · 2026

    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.

    Papers in Europe PMC
  7. 07
    Zafereo M5 papers · 2026

    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

    Papers in Europe PMC
  8. 08
    Busaidy NL4 papers · 2026

    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, Texas.

    Papers in Europe PMC
  9. 09
    Chen J4 papers · 2026

    Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, China.

    Papers in Europe PMC
  10. 10
    Guo Y4 papers · 2026

    Department of Thyroid Center/Thyroid Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

48

interventional trials for this specific condition

48 interventional trials matched this specific condition name; 7 currently recruiting in our sample.

Data as of 27 July 2026

48 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 97th percentile).

high confidence · 97th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

48 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

6 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Anaplastic thyroid carcinoma" OR "Dedifferentiated thyroid gland carcinoma" OR "anaplastic carcinoma of the thyroid" OR "anaplastic carcinoma of thyroid" OR "anaplastic carcinoma of the thyroid gland" OR "anaplastic carcinoma of thyroid gland" OR "anaplastic thyroid cancer" OR "anaplastic thyroid gland carcinoma" OR "metaplastic thyroid gland carcinoma" OR "pleomorphic thyroid gland carcinoma" OR "sarcomatoid thyroid gland carcinoma" OR "thyroid gland carcinosarcoma" OR "thyroid gland undifferentiated (anaplastic) carcinoma" OR "thyroid gland undifferentiated carcinoma" OR "undifferentiated (anaplastic) thyroid gland cancer" OR "undifferentiated (anaplastic) thyroid gland carcinoma" OR "undifferentiated carcinoma of the thyroid" OR "undifferentiated carcinoma of thyroid" OR "undifferentiated carcinoma of the thyroid gland" OR "undifferentiated carcinoma of thyroid gland" OR "undifferentiated thyroid carcinoma" OR "undifferentiated thyroid gland carcinoma" OR "undifferentiated thyroid tumor" OR "undifferentiated thyroid tumour"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Anaplastic thyroid carcinoma" OR "Dedifferentiated thyroid gland carcinoma" OR "anaplastic carcinoma of the thyroid" OR "anaplastic carcinoma of thyroid" OR "anaplastic carcinoma of the thyroid gland" OR "anaplastic carcinoma of thyroid gland" OR "anaplastic thyroid cancer" OR "anaplastic thyroid gland carcinoma" OR "metaplastic thyroid gland carcinoma" OR "pleomorphic thyroid gland carcinoma" OR "sarcomatoid thyroid gland carcinoma" OR "thyroid gland carcinosarcoma" OR "thyroid gland undifferentiated (anaplastic) carcinoma" OR "thyroid gland undifferentiated carcinoma" OR "undifferentiated (anaplastic) thyroid gland cancer" OR "undifferentiated (anaplastic) thyroid gland carcinoma" OR "undifferentiated carcinoma of the thyroid" OR "undifferentiated carcinoma of thyroid" OR "undifferentiated carcinoma of the thyroid gland" OR "undifferentiated carcinoma of thyroid gland" OR "undifferentiated thyroid carcinoma" OR "undifferentiated thyroid gland carcinoma" OR "undifferentiated thyroid tumor" OR "undifferentiated thyroid tumour"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 48 interventional · 6 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T12:37:39.215Z