ORPHA:141103
Nasal dermoid cyst
Also known as: Nasal dermoid sinus cyst
Publications
124
58.1th percentile
Trials
0
Interventional, condition-specific
Researchers
507
Distinct authors in sample
Gene link
—
Readiness
2/6
Stages with a signal
Clinical definition (Orphanet)
A rare otorhinolaryngological characterized by a dermoid cyst along the nasal dorsum or glabella, lined by keratinized squamous epithelium and containing intraluminal keratin and mature adnexal structures, such as hair follicles, sebaceous and sweat glands. The majority of nasal dermoid cysts are superficial, rarely they extend intracranially. The cysts are typically benign but are susceptible to recurrent infections that may progress to osteomyelitis, meningitis or an intracranial abscess.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0010921
- MeSH:C563455
- OMIM:600679
- UMLS:C1833473
Additional Mondo synonyms (1)
nasal dermoid sinus cyst
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
2/6 stages with a signal
No specific-condition interventional trial, but broader-category trials exist — discuss eligibility with a clinician.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
124 matched papers (63 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialPartial
None under the specific name; 2 for broader category dermoid cyst
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
124
124 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
124 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
63 in the last 10 years · high confidence · 58.1th percentile (publications denominator)
Phrase hits: 124 · MeSH hits: 0
Who's working on it?
507
Distinct author names in 124 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Patel VA4 papers · 2025
Department of Otolaryngology, UPMC Center for Cranial Base Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Papers in Europe PMC - 02Brylla E2 papers · 2008Papers in Europe PMC
- 03Charrier JB2 papers · 2005
Service d'ORL pédiatrique et de chirurgie cervico-faciale, Hôpital d'enfants Armand-Trousseau, 26, rue du Dr Arnold Netter, 75012 Paris, France. jean-baptiste.charrier@college-de-france.fr
Papers in Europe PMC - 04Chowdhary A2 papers · 2019
ENT Clinic, Residency Road, Opposite Church-gate, Jammu, Jammu and Kashmir 180001 India.
Papers in Europe PMC - 05Denoyelle F2 papers · 2005Papers in Europe PMC
- 06Frerich B2 papers · 2008Papers in Europe PMC
- 07Hemprich A2 papers · 2008Papers in Europe PMC
- 08Jang YJ2 papers · 2013Papers in Europe PMC
- 09Kim JH2 papers · 2022
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Papers in Europe PMC - 10Levy ML2 papers · 2025
Division of Pediatric Neurosurgery, Rady Children's Hospital, San Diego, CA 92123, USA.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name. 1 observational study did — shown below because natural-history and cohort work can be an important step toward a trial. 2 trials are registered for dermoid cyst, the broader category — shown separately because they may or may not enrol this specific subtype.
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
high confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
2 interventional trials matched dermoid cyst, the broader category — listed below. Those studies are not counted in the condition-specific total.
Broader category: dermoid cyst
2
Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.
Worth raising with a clinician. How we count trials.
Observational and natural-history studies
1 observational study matches this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.
None of the matched observational studies is currently listed as recruiting.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Nasal dermoid cyst" OR "Nasal dermoid sinus cyst"
MeSH descriptor terms unioned into the query: Dermoid Cysts, Familial Frontonasal
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Nasal dermoid cyst" OR "Nasal dermoid sinus cyst" OR "Dermoid Cysts, Familial Frontonasal" OR "nasal disorder"
Recall-expansion terms: nasal disorder
Study-type breakdown: 0 interventional · 1 observational · 0 expanded access. Only interventional studies enter the trial headline.
Parent-category trials query:
"dermoid cyst"
Query health: ok — strategies attempted: phrase, mesh, recall-expansion; with hits: phrase, recall-expansion
Run this search on ClinicalTrials.gov
Confidence reasoning
- Preferred label is multi-word and distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-27T07:52:09.422Z