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ORPHA:139417

Acute transverse myelitis

high confidenceDisorder

Publications

1,826

87.6th percentile

Trials

4

Interventional, condition-specific

Researchers

961

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare inflammatory demyelinating disorder of the spinal cord that can be either (IATM) or secondary to a known cause (SATM).

How rare: 1-9 / 100 000 — about one to nine people per hundred thousand.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    1,826 matched papers (1,070 in last 10 years) Source

  3. Phenotype characterisedPresent

    53 HPO annotations (e.g. CSF pleocytosis; Spasticity; Fever) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    4 matched on ClinicalTrials.gov (1 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

53

Associated phenotypes · MONDO:0015342

  • CSF pleocytosis
  • Spasticity
  • Fever
  • Paraparesis
  • Impaired vibratory sensation

Showing 5 of 53 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

7 associated chemicals. Therapeutic evidence is listed first when present — not a treatment recommendation.

  • Cytarabine · marker/mechanism
  • Heroin · marker/mechanism
  • Mechlorethamine · marker/mechanism
  • Methotrexate · marker/mechanism
  • Nandrolone · marker/mechanism
  • Vinblastine · marker/mechanism
  • Vitamin B 12 · marker/mechanism

MyDisease.info · MONDO:0015342

Literature

Is anyone studying this?

1,826

1,826 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

1,826 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

1,070 in the last 10 years · high confidence · 87.6th percentile (publications denominator)

Phrase hits: 1,773 · MeSH hits: 56

Open Europe PMC search

Who's working on it?

961

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Li Y4 papers · 2025

    Department of Radiology, The First Hospital of Changsha, Changsha, Hunan, China.

    Papers in Europe PMC
  2. 02
    Garg RK3 papers · 2026

    Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.

    Papers in Europe PMC
  3. 03
    Li S3 papers · 2026

    Department of Urology, The Third Central Hospital of Tianjin, 83 Jintang Road, Hedong District, Tianjin, 300170, China.

    Papers in Europe PMC
  4. 04
    Zhang Y3 papers · 2026

    Department of Gastroenterology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, China. hxzyan@163.com.

    Papers in Europe PMC
  5. 05
    Zhou Y3 papers · 2026

    Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.

    Papers in Europe PMC
  6. 06
    Andalib S2 papers · 2025

    Research Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

    Papers in Europe PMC
  7. 07
    Berger T2 papers · 2025

    Medical University of Vienna, Department of Neurology, Austria; Medical University of Vienna, Comprehensive Center for Clinical Neurosciences and Mental Health, Austria.

    Papers in Europe PMC
  8. 08
    Bsteh G2 papers · 2025

    Medical University of Vienna, Department of Neurology, Austria; Medical University of Vienna, Comprehensive Center for Clinical Neurosciences and Mental Health, Austria.

    Papers in Europe PMC
  9. 09
    Cartabellotta F2 papers · 2025

    Internal Medicine Ward, Buccheri La Ferla Hospital, 90100 Palermo, Italy.

    Papers in Europe PMC
  10. 10
    Chakraborty R2 papers · 2025

    Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

4

interventional trials for this specific condition

4 interventional trials matched this specific condition name; 1 currently recruiting in our sample. 12 trials are registered for myelitis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

4 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 88.1th percentile).

high confidence · 88.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

4 interventional trials matched after quoted-phrase search and title/condition post-filter.

Broader category: myelitis

12

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Observational and natural-history studies

2 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

None of the matched observational studies is currently listed as recruiting.

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 10 · after dedupe 10 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 10 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (10)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Acute transverse myelitis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Acute transverse myelitis"

Run this search on Europe PMC

MeSH descriptor terms unioned into the query: Myelitis, Transverse

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Acute transverse myelitis" OR "Myelitis, Transverse"

Interventional trials matched via: phrase, mesh (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 4 interventional · 2 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"myelitis"

Query health: ok — strategies attempted: phrase, mesh; with hits: phrase, mesh

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T07:35:10.902Z