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ORPHA:137686

Asherman syndrome

medium confidenceDisorder

Publications

3,758

96.2th percentile

Trials

53

Interventional, condition-specific

Researchers

975

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss).

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

Asherman's Syndrome · intrauterine adhesions · intrauterine synechiae

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    3,758 matched papers (2,896 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    53 matched on ClinicalTrials.gov (13 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

3,758

3,758 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

3,758 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

2,896 in the last 10 years · medium confidence · 96.2th percentile (publications denominator)

Phrase hits: 3,758 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

975

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang H13 papers · 2026

    Dalian Medical University, Dalian, China.

    Papers in Europe PMC
  2. 02
    Zhang Y12 papers · 2026

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun East Road, Jianggan District, Hangzhou, 310016, China.; Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, No. Qingchun East Road, Jianggan District, Hangzhou, 310016, China.

    Papers in Europe PMC
  3. 03
    Zhang X8 papers · 2026

    Department of Obstetrics and Gynecology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

    Papers in Europe PMC
  4. 04
    Li Y7 papers · 2026

    The Sun Yat-Sen Memorial Hospital Department of Obstetrics and Gynecology, Sun Yat-Sen University, Guangdong, 510080, China.

    Papers in Europe PMC
  5. 05
    Liu D7 papers · 2026

    Department of Reproductive Endocrinology, West China Second University Hospital, Sichuan University (Liu, Liu, and Ouyang), Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education (Qiao, Liu, Liu, Pei, and Ouyang), Chengdu, China.

    Papers in Europe PMC
  6. 06
    Wang J7 papers · 2026

    Department of Obstetrics and Gynecology, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China. Electronic address: 800026@hospital.cqmu.edu.cn.

    Papers in Europe PMC
  7. 07
    Wang X7 papers · 2026

    School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.

    Papers in Europe PMC
  8. 08
    Xu D7 papers · 2026

    Department of Gynecology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, Hunan, 410013, China. dabaoxu2022@163.com.

    Papers in Europe PMC
  9. 09
    Yang X7 papers · 2026

    Department of Obstetrics, The Fifth People's Hospital of Chengdu, Chengdu, China.

    Papers in Europe PMC
  10. 10
    Zhang W7 papers · 2026

    Reproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, Air Force Medical University, (Drs. Zhang, Tang, Xiao, Liu, Li and Wang) Xi'an, Shaanxi, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

53

interventional trials for this specific condition

53 interventional trials matched this specific condition name; 13 currently recruiting in our sample.

Data as of 27 July 2026

53 interventional trials — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 97.1th percentile).

medium confidence · 97.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

53 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

9 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Asherman syndrome" OR "Asherman's Syndrome" OR "intrauterine adhesions" OR "intrauterine synechiae"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Asherman syndrome" OR "Asherman's Syndrome" OR "intrauterine adhesions" OR "intrauterine synechiae"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 53 interventional · 9 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T07:28:20.081Z