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ORPHA:137686

Asherman syndrome

medium confidenceDisorder

Publications

3,758

92th percentile

Trials

53

Interventional, condition-specific

Researchers

975

Distinct authors in sample

Gene link

—

Readiness

4/6

Stages with a signal

Clinical definition (Orphanet)

A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss).

How rare: 1-5 / 10 000 — about one to five people per ten thousand (still uncommon, but less ultra-rare).

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (3)

Asherman's Syndrome · intrauterine adhesions · intrauterine synechiae

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

4/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    3,758 matched papers (2,896 in last 10 years) Source

  3. Phenotype characterisedPresent

    10 HPO annotations (e.g. Episodic abdominal pain; Abnormal placenta morphology; Abnormality of the menstrual cycle) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationPartial

    1 EMA designation (none yet with FDA orphan-indication approval) — e.g. autologous adult bone marrow-derived non-expanded CD133+ haematopoietic stem cells Source

  6. Interventional trialPresent

    53 matched on ClinicalTrials.gov (13 recruiting in sample)

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

10

Associated phenotypes · MONDO:0015299

  • Episodic abdominal pain
  • Abnormal placenta morphology
  • Abnormality of the menstrual cycle
  • Oligomenorrhea
  • Dysmenorrhea

Showing 5 of 10 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

1

Designation · no FDA orphan-indication approval yet

  • EMA autologous adult bone marrow-derived non-expanded CD133+ haematopoietic stem cellsTreatment of Asherman's syndrome · 20/04/2017 · PositiveEMA designation

Sources: FDA OOPD · EMA orphan designations

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

3,758

3,758 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

3,758 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

2,896 in the last 10 years · medium confidence · 92th percentile (publications denominator)

Phrase hits: 3,758 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

975

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Wang H13 papers · 2026

    Dalian Medical University, Dalian, China.

    Papers in Europe PMC
  2. 02
    Zhang Y12 papers · 2026

    Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3 Qingchun East Road, Jianggan District, Hangzhou, 310016, China.; Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, No. Qingchun East Road, Jianggan District, Hangzhou, 310016, China.

    Papers in Europe PMC
  3. 03
    Zhang X8 papers · 2026

    Department of Obstetrics and Gynecology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

    Papers in Europe PMC
  4. 04
    Li Y7 papers · 2026

    The Sun Yat-Sen Memorial Hospital Department of Obstetrics and Gynecology, Sun Yat-Sen University, Guangdong, 510080, China.

    Papers in Europe PMC
  5. 05
    Liu D7 papers · 2026

    Department of Reproductive Endocrinology, West China Second University Hospital, Sichuan University (Liu, Liu, and Ouyang), Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education (Qiao, Liu, Liu, Pei, and Ouyang), Chengdu, China.

    Papers in Europe PMC
  6. 06
    Wang J7 papers · 2026

    Department of Obstetrics and Gynecology, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China. Electronic address: 800026@hospital.cqmu.edu.cn.

    Papers in Europe PMC
  7. 07
    Wang X7 papers · 2026

    School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.

    Papers in Europe PMC
  8. 08
    Xu D7 papers · 2026

    Department of Gynecology, Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, Hunan, 410013, China. dabaoxu2022@163.com.

    Papers in Europe PMC
  9. 09
    Yang X7 papers · 2026

    Department of Obstetrics, The Fifth People's Hospital of Chengdu, Chengdu, China.

    Papers in Europe PMC
  10. 10
    Zhang W7 papers · 2026

    Reproductive Medicine Center, Department of Gynecology and Obstetrics, Tangdu Hospital, Air Force Medical University, (Drs. Zhang, Tang, Xiao, Liu, Li and Wang) Xi'an, Shaanxi, China.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

53

interventional trials for this specific condition

53 interventional trials matched this specific condition name; 13 currently recruiting in our sample.

Data as of 11 September 2026

53 interventional trials — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 97.3th percentile).

medium confidence · 97.3th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

53 interventional trials matched after quoted-phrase search and title/condition post-filter.

Observational and natural-history studies

9 observational studies match this condition. These do not test a treatment and are not counted in the interventional-trial headline, but they are genuine research: natural-history work often defines the endpoints needed for a future rare-disease trial, and families may be able to enroll.

Recruiting or not-yet-recruiting

Open the complete matched search on ClinicalTrials.gov

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 15 · after dedupe 15 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 15 · dropped 0 · fetched 2026-07-30

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (15)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Asherman syndrome — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Asherman syndrome" OR "Asherman's Syndrome" OR "intrauterine adhesions" OR "intrauterine synechiae"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Asherman syndrome" OR "Asherman's Syndrome" OR "intrauterine adhesions" OR "intrauterine synechiae"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 53 interventional · 9 observational · 0 expanded access. Only interventional studies enter the trial headline.

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is short or not clearly distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-27T07:28:20.081Z