ORPHA:1305
Feingold syndrome
Also known as: Brunner-Winter syndrome · Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum · FGLDS · FS · MMT · MODED syndrome · Microcephaly-digital anomalies-normal intelligence syndrome · Microcephaly-intellectual disability-tracheoesophageal fistula syndrome · Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome · ODED syndrome · Oculo-digito-esophageal-duodenal syndrome
Publications
839
Trials
0
Interventional, condition-specific
Researchers
1,204
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
A rare genetic, syndrome characterized by microcephaly, short stature and numerous digital anomalies (brachymesophanlangy, fifth finger clinodactyly, syndactyly of toes and hypoplastic thumbs), mild learning deficit and short palpebral fissures. The two subtypes are clinically distinguished by the presence (type 1) or absence (type 2) gastrointestinal atresia.
How rare: <1 / 1 000 000 — fewer than one in a million. In a city the size of Kolkata, that might mean on the order of fifteen people.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0015267
- UMLS:C0796068
- NCIT:C74987
Additional Mondo synonyms (6)
digital anomalies with short palpebral fissures and atresia of esophagus or duodenum · digital anomalies with short palpebral fissures and atresia of oesophagus or duodenum · microcephaly-digital anomalies-normal intelligence syndrome · microcephaly-intellectual disability-tracheoesophageal fistula syndrome · microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome · oculo-digito-esophageal-duodenal syndrome
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
839 matched papers (471 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
839
839 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
839 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
471 in the last 10 years · low confidence
Phrase hits: 839 · MeSH hits: 0
Who's working on it?
1,204
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Cheng T4 papers · 2025
Institute of Genetics and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, China.
Papers in Europe PMC - 02Zhang Y4 papers · 2026
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Papers in Europe PMC - 03Chen Y3 papers · 2025
Obstetrics and Gynecology Hospital of Fudan University, Fudan University Shanghai Medical College, Shanghai, China.
Papers in Europe PMC - 04Doki Y3 papers · 2025
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Papers in Europe PMC - 05Dong Y3 papers · 2025
Institute of Genetics and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, China.
Papers in Europe PMC - 06Eguchi H3 papers · 2025
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Papers in Europe PMC - 07Hamabe A3 papers · 2025
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Papers in Europe PMC - 08Hata T3 papers · 2025
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Papers in Europe PMC - 09Huang Y3 papers · 2022
Department of Pediatrics, Shenzhen Nanshan Maternity and Child Healthcare Hospital, Shenzhen, China.
Papers in Europe PMC - 10Kato K3 papers · 2024
Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
low confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Feingold syndrome" OR "Brunner-Winter syndrome" OR "Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum" OR "Digital anomalies with short palpebral fissures and atresia of the esophagus or duodenum" OR "FGLDS" OR "MODED syndrome" OR "Microcephaly-digital anomalies-normal intelligence syndrome" OR "Microcephaly-intellectual disability-tracheoesophageal fistula syndrome" OR "Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome" OR "ODED syndrome" OR "Oculo-digito-esophageal-duodenal syndrome" OR "digital anomalies with short palpebral fissures and atresia of oesophagus or duodenum" OR "digital anomalies with short palpebral fissures and atresia of the oesophagus or duodenum"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Feingold syndrome" OR "Brunner-Winter syndrome" OR "Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum" OR "Digital anomalies with short palpebral fissures and atresia of the esophagus or duodenum" OR "FGLDS" OR "MODED syndrome" OR "Microcephaly-digital anomalies-normal intelligence syndrome" OR "Microcephaly-intellectual disability-tracheoesophageal fistula syndrome" OR "Microcephaly-oculo-digito-esophageal-duodenal syndrome syndrome" OR "ODED syndrome" OR "Oculo-digito-esophageal-duodenal syndrome" OR "digital anomalies with short palpebral fissures and atresia of oesophagus or duodenum" OR "digital anomalies with short palpebral fissures and atresia of the oesophagus or duodenum"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: FS; MMT
Confidence reasoning
- Preferred label is short or not clearly distinctive
- 2 synonym(s) dropped by stoplist (may under-count)
- No label/synonym collisions with other diseases in this corpus
- Publication count (839) is implausibly high for prevalence class "<1 / 1 000 000" — treat as possible over-matching, not a measure of research intensity
Ingested 2026-07-26T16:59:01.752Z