ORPHA:128
Diphyllobothriasis
Also known as: Bothriocephalosis
Publications
1,142
81.5th percentile
Trials
0
Interventional, condition-specific
Researchers
897
Distinct authors in sample
Gene link
—
Readiness
1/6
Stages with a signal
Clinical definition (Orphanet)
Bothriocephalosis is a mammalian cosmopolitan intestinal parasitosis. In addition to non-specific digestive problems (nausea, abdominal pain, lack of appetite), bothriocephalosis provokes an anaemia caused by vitamin B12 deficiency that resembles Biermer anaemia (anaemia characterised by abnormally large red blood cells).
How rare: 1-9 / 1 000 000 — roughly one to nine people per million. In a city the size of Kolkata, perhaps a few dozen.
Cross-references
Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.
- MONDO:0015260
- MeSH:D004169
- UMLS:C0012561
- NCIT:C128391
Additional Mondo synonyms (5)
Diphyllobothrium caused disease or disorder · Diphyllobothrium disease or disorder · Diphyllobothrium infection · Diphyllobothrium infectious disease · fish tapeworm
Research stages
Trial readiness signals
Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”
1/6 stages with a signal
Research-stage checklist from open sources (GenCC, literature, Monarch when enriched, ClinicalTrials.gov). Not a prognosis or care recommendation.
- Gene identifiedNot found
No GenCC disease–gene assertion in this build
- LiteraturePresent
1,142 matched papers (242 in last 10 years) Source
- Phenotype characterisedNot checked
Not yet enriched from Monarch / HPO
- Animal modelNot checked
Not yet enriched from Monarch / Alliance
- Orphan designationNot checked
FDA/EMA orphan-drug designation not enriched yet
- Interventional trialNot found
No matched interventional trial under our ClinicalTrials.gov rules
Biology
Genes and phenotypes
Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.
Do we know what causes it?
Not yet — the cause hasn't been pinned down in GenCC.
No strong gene–disease assertion joined for this Orphanet entity.
Phenotypes (Monarch / HPO)
Not enriched in this build — Monarch phenotype joins were not run for this record.
Animal models (Monarch / Alliance)
Not enriched in this build.
Literature
Is anyone studying this?
1,142
1,142 papers have been published on this condition. That is a real research literature — still far smaller than common diseases (breast cancer: over 700,000 papers). Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.
1,142 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).
242 in the last 10 years · medium confidence · 81.5th percentile (publications denominator)
Phrase hits: 1,142 · MeSH hits: 0
Who's working on it?
897
Distinct author names in 200 sampled papers — named people below.
Who's working on it?
No interventional trial matched this name; these authors publish on it in the sampled literature — a practical starting point for contact.
- 01Scholz T21 papers · 2025
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, 370 05 České Budějovice, Czech Republic.
Papers in Europe PMC - 02Kuchta R19 papers · 2025
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, 370 05 České Budějovice, Czech Republic. Electronic address: krtek@paru.cas.cz.
Papers in Europe PMC - 03Brabec J9 papers · 2025
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, 370 05 České Budějovice, Czech Republic.
Papers in Europe PMC - 04Králová-Hromadová I8 papers · 2023
Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 04001, Košice, Slovakia, hromadova@saske.sk.
Papers in Europe PMC - 05Radačovská A7 papers · 2023
Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 04001 Košice, Slovakia.
Papers in Europe PMC - 06Bazsalovicsová E6 papers · 2019
Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 04001 Košice, Slovakia.
Papers in Europe PMC - 07Mitchell PD5 papers · 2025
Department of Archaeology, University of Cambridge, The Henry Wellcome Building, Fitzwilliam Street, Cambridge CB2 1QH, UK.
Papers in Europe PMC - 08Viozzi G5 papers · 2026
Laboratorio de Parasitología, INIBIOMA (Universidad Nacional del Comahue-CONICET), (8400) Av. Quintral 1250, San Carlos de Bariloche, Río Negro, Argentina. Electronic address: gviozzi@gmail.com.
Papers in Europe PMC - 09Arbetman M4 papers · 2024
Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural (IRNAD)-Universidad Nacional de Río Negro, (8400) Mitre 630, San Carlos de Bariloche, Río Negro, Argentina; Laboratorio Ecotono, Centro Regional Universitario Bariloche, Universidad Nacional del Comahue, (8400) Pasaje Gutiérrez 1125, San Carlos de Bariloche, Río Negro, Argentina.
Papers in Europe PMC - 10Choudhury A4 papers · 2024
Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 04001 Košice, Slovak Republic.
Papers in Europe PMC
Clinical research
Is a treatment being tested?
0
interventional trials for this specific condition
No interventional trial testing a treatment matched this specific condition name on ClinicalTrials.gov (observational studies and pan-disease registries are listed separately when present).
Data as of 27 July 2026
No matched interventional trials. This is true for 73% of diseases in the trials denominator (5114 of 7003). Here are the researchers publishing on it.
medium confidence · 36.5th percentile (trials denominator)
Recruiting interventional trials
From the matched ClinicalTrials.gov set
No interventional trial testing a treatment was found for this specific condition name on ClinicalTrials.gov.
See who's working on it — people publishing on this disease are often the practical next contact when no trial is listed.
Where to find support
We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:
India — NPRD
Last verified 2026-07-26This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.
Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.
How we counted this
Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.
"Diphyllobothriasis" OR "Bothriocephalosis" OR "Diphyllobothrium infection" OR "Diphyllobothrium infectious disease" OR "fish tapeworm"
ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):
"Diphyllobothriasis" OR "Bothriocephalosis" OR "Diphyllobothrium infection" OR "Diphyllobothrium infectious disease" OR "fish tapeworm"
Study-type breakdown: 0 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.
Query health: ok — strategies attempted: phrase; with hits: phrase
Run this search on ClinicalTrials.gov
Synonyms dropped by stoplist: Diphyllobothrium caused disease or disorder; Diphyllobothrium disease or disorder
Confidence reasoning
- Preferred label is short or not clearly distinctive
- No synonyms dropped by stoplist
- No label/synonym collisions with other diseases in this corpus
Ingested 2026-07-26T12:32:42.558Z