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ORPHA:1077

Dental ankylosis

high confidenceDisorder

Also known as: Ankylosis of teeth

Publications

428

82.5th percentile

Trials

1

Interventional, condition-specific

Researchers

923

Distinct authors in sample

Gene link

—

Readiness

2/6

Stages with a signal

Clinical definition (Orphanet)

A rare odontologic disorder characterized by the loss of the periodontal ligament space and orthodontic mobility.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

ankylosis (disease) of calcareous tooth · ankylosis of teeth · ankylosis of tooth · calcareous tooth ankylosis (disease)

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

2/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    428 matched papers (259 in last 10 years) Source

  3. Phenotype characterisedNot checked

    Not yet enriched from Monarch / HPO

  4. Animal modelNot checked

    Not yet enriched from Monarch / Alliance

  5. Orphan designationNot checked

    FDA/EMA orphan-drug designation not enriched yet

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

Not enriched in this build — Monarch phenotype joins were not run for this record.

Animal models (Monarch / Alliance)

Not enriched in this build.

Literature

Is anyone studying this?

428

428 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=5449) is 41.

428 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 41 (publications denominator n=5449).

259 in the last 10 years · high confidence · 82.5th percentile (publications denominator)

Phrase hits: 428 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

923

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Andreasen JO4 papers · 2025

    Department of Oral and Maxillofacial Surgery, University Hospital, Copenhagen, Denmark.

    Papers in Europe PMC
  2. 02
    Reisz RR4 papers · 2022

    Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.

    Papers in Europe PMC
  3. 03
    Andersson L3 papers · 2024

    Department of Oral and Maxillofacial Surgery and Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.

    Papers in Europe PMC
  4. 04
    Consolaro A3 papers · 2023

    Full professor, Universidade de São Paulo (USP), Undergraduate program, Bauru, São Paulo, Brazil and Universidade de São Paulo (USP), Graduate program, Ribeirão Preto, São Paulo, Brazil., Universidade de São Paulo, Universidade de São Paulo, Bauru São Paulo , Brazil.

    Papers in Europe PMC
  5. 05
    Gerds TA3 papers · 2025

    Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

    Papers in Europe PMC
  6. 06
    Grippaudo C3 papers · 2025

    Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy.

    Papers in Europe PMC
  7. 07
    Lauridsen E3 papers · 2024

    Department of Oral and Maxillofacial Surgery, University Hospital, Copenhagen, Denmark.

    Papers in Europe PMC
  8. 08
    Nomura R3 papers · 2025

    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.

    Papers in Europe PMC
  9. 09
    Tabolacci E3 papers · 2025

    Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Medicina Genomica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

    Papers in Europe PMC
  10. 10
    Yuan X3 papers · 2026

    Department of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indiana, Indianapolis, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting. 9 trials are registered for ankylosis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 27 July 2026

1 interventional trial — more than 73% of diseases in the trials denominator have none at all (5114 of 7003; this disease is at the 76.8th percentile).

high confidence · 76.8th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: ankylosis

9

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Where to find support

We do not yet link condition-specific patient organisations. These umbrella groups support undiagnosed and ultra-rare families:

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Dental ankylosis" OR "Ankylosis of teeth" OR "Ankylosis of the teeth" OR "ankylosis (disease) of calcareous tooth" OR "ankylosis (disease) of the calcareous tooth" OR "ankylosis of tooth" OR "ankylosis of the tooth" OR "calcareous tooth ankylosis (disease)"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Dental ankylosis" OR "Ankylosis of teeth" OR "Ankylosis of the teeth" OR "ankylosis (disease) of calcareous tooth" OR "ankylosis (disease) of the calcareous tooth" OR "ankylosis of tooth" OR "ankylosis of the tooth" OR "calcareous tooth ankylosis (disease)"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"ankylosis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T16:21:23.935Z