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ORPHA:1077

Dental ankylosis

high confidenceDisorder

Also known as: Ankylosis of teeth

Publications

428

72.5th percentile

Trials

1

Interventional, condition-specific

Researchers

923

Distinct authors in sample

Gene link

—

Readiness

3/6

Stages with a signal

Clinical definition (Orphanet)

A rare odontologic disorder characterized by the loss of the periodontal ligament space and orthodontic mobility.

How rare: How common this is has not been clearly measured.

Orphanet entry

Cross-references

Joined from Mondo / Orphanet. MeSH labels may enter searches; UMLS / OMIM / NCIT are stored for reference.

Additional Mondo synonyms (4)

ankylosis (disease) of calcareous tooth · ankylosis of teeth · ankylosis of tooth · calcareous tooth ankylosis (disease)

Research stages

Trial readiness signals

Where this condition sits on an open-data research pipeline — not how close a treatment is, and not medical advice. Empty stages often mean “not in these databases under this Mondo ID,” not “impossible.”

3/6 stages with a signal

An interventional trial matched this condition name on ClinicalTrials.gov — see trials below.

  1. Gene identifiedNot found

    No GenCC disease–gene assertion in this build

  2. LiteraturePresent

    428 matched papers (259 in last 10 years) Source

  3. Phenotype characterisedPresent

    7 HPO annotations (e.g. Mandibular prognathia; Abnormal dental enamel morphology; Clinodactyly of the 5th finger) Source

  4. Animal modelNot found

    No Alliance genotype “model of” associations via Monarch for these Mondo IDs

  5. Orphan designationNot found

    No FDA or EMA orphan-drug designation matched this disease via UMLS or preferred name Source

  6. Interventional trialPresent

    1 matched on ClinicalTrials.gov

Biology

Genes and phenotypes

Gene–disease validity from GenCC, plus phenotypes and animal models joined from Monarch Initiative via Mondo ID — not a clinical diagnosis aid.

Do we know what causes it?

Not yet — the cause hasn't been pinned down in GenCC.

No strong gene–disease assertion joined for this Orphanet entity.

Phenotypes (Monarch / HPO)

7

Associated phenotypes · MONDO:0008007

  • Mandibular prognathia
  • Abnormal dental enamel morphology
  • Clinodactyly of the 5th finger
  • Tooth agenesis
  • Abnormality of the dentition

Showing 5 of 7 — open Monarch for the full list.

Animal models (Monarch / Alliance)

None returned for this Mondo ID. Empty here is not proof that no model organism work exists under another name or gene.

Monarch fetch 2026-07-29

Therapies

Designations, candidates, and chemicals

FDA OOPD and EMA orphan designations, Open Targets clinical candidates, and CTD chemical associations via MyDisease.info. These never change the interventional-trial headline.

Orphan designation (FDA · EMA)

No designation matched this disease via UMLS or preferred name on the FDA OOPD mirror or EMA orphan register. Absence here is not proof that none exists under another wording.

Open Targets candidates

No drugs or clinical candidates returned for this Mondo ID on Open Targets.

CTD chemicals (MyDisease.info)

No CTD chemical associations returned for this Mondo ID.

Literature

Is anyone studying this?

428

428 papers have ever been published on this condition (under this name). For scale, breast cancer has over 700,000. Median papers in the last 10 years for a rare disease in this dataset (publications denominator n=3967) is 59.

428 papers since the earliest indexed year in this search — median last-10-year count for a rare disease in this dataset is 59 (publications denominator n=3967).

259 in the last 10 years · high confidence · 72.5th percentile (publications denominator)

Phrase hits: 428 · MeSH hits: 0

Open Europe PMC search

Who's working on it?

923

Distinct author names in 200 sampled papers — named people below.

Who's working on it?

People publishing on this condition (sampled Europe PMC records). Affiliation is the most recent found in that sample.

  1. 01
    Andreasen JO4 papers · 2025

    Department of Oral and Maxillofacial Surgery, University Hospital, Copenhagen, Denmark.

    Papers in Europe PMC
  2. 02
    Reisz RR4 papers · 2022

    Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.

    Papers in Europe PMC
  3. 03
    Andersson L3 papers · 2024

    Department of Oral and Maxillofacial Surgery and Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.

    Papers in Europe PMC
  4. 04
    Consolaro A3 papers · 2023

    Full professor, Universidade de São Paulo (USP), Undergraduate program, Bauru, São Paulo, Brazil and Universidade de São Paulo (USP), Graduate program, Ribeirão Preto, São Paulo, Brazil., Universidade de São Paulo, Universidade de São Paulo, Bauru São Paulo , Brazil.

    Papers in Europe PMC
  5. 05
    Gerds TA3 papers · 2025

    Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

    Papers in Europe PMC
  6. 06
    Grippaudo C3 papers · 2025

    Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy.

    Papers in Europe PMC
  7. 07
    Lauridsen E3 papers · 2024

    Department of Oral and Maxillofacial Surgery, University Hospital, Copenhagen, Denmark.

    Papers in Europe PMC
  8. 08
    Nomura R3 papers · 2025

    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka 565-0871, Japan.

    Papers in Europe PMC
  9. 09
    Tabolacci E3 papers · 2025

    Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Medicina Genomica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.

    Papers in Europe PMC
  10. 10
    Yuan X3 papers · 2026

    Department of Otolaryngology-Head & Neck Surgery, Indiana University School of Medicine, Indiana, Indianapolis, USA.

    Papers in Europe PMC

Clinical research

Is a treatment being tested?

1

interventional trials for this specific condition

1 interventional trial matched this specific condition name; none in our sample are currently recruiting. 9 trials are registered for ankylosis, the broader category — shown separately because they may or may not enrol this specific subtype.

Data as of 11 September 2026

1 interventional trial — more than 77.2% of diseases in the trials denominator have none at all (5501 of 7126; this disease is at the 80.1th percentile).

high confidence · 80.1th percentile (trials denominator)

Recruiting interventional trials

From the matched ClinicalTrials.gov set

1 interventional trials matched after quoted-phrase search and title/condition post-filter.

No currently recruiting studies in the matched set. Open the same search on ClinicalTrials.gov.

Broader category: ankylosis

9

Interventional trials for the parent category, exclusive of NCT IDs already counted above. Eligibility for this subtype is not guaranteed.

Worth raising with a clinician. How we count trials.

Recruiting under the broader category

Other registries (secondary)

Broader net from EU CTIS, ISRCTN, and ICTRP when available — deduped against ClinicalTrials.gov IDs already counted above. Dual-model LLM relevance gates what we keep. These rows are not added to the interventional headline.

raw 1 · after dedupe 1 · already on CT.gov 0 · kept 0 · parent 0 · uncertain 1 · dropped 0 · fetched 2026-07-29

Source notes: ictrp: Error: ICTRP public search unavailable (WHO portal is SPA-only; SOAP needs partnership). Tried: https://apps.who.int/tri

No secondary-registry studies passed dual-model relevance for this condition name (after dedupe).

Uncertain / not reviewed (1)

Where to find support

Condition-specific patient organisations, when Orphanet lists them, are on the disease’s Orphanet page. We also link umbrella groups that support undiagnosed and ultra-rare families.

Orphanet entry for Dental ankylosis — check Associations / patient organisations on that page.

India — NPRD

Last verified 2026-07-26

This ORPHAcode is not on our curated NPRD list (direct or Mondo-parent match). That does not decide clinical eligibility; families in India should ask a notified Centre of Excellence about current coverage.

Hand-curated for this project. ORPHAcode mappings are best-effort and may be incomplete or imprecise for umbrella categories. Parent (Mondo) matches mean the policy lists a broader category — confirm eligibility with a Centre of Excellence. Financial entitlements summarised from public policy statements and may change. This is not official government guidance.

How we counted this

Europe PMC query (preferred label + any corrected label + Orphanet and Mondo exact synonyms, stoplisted; unioned with resolved MeSH labels when available). UMLS / OMIM / NCIT cross-references are stored on the overview but are not added to the query string.

"Dental ankylosis" OR "Ankylosis of teeth" OR "Ankylosis of the teeth" OR "ankylosis (disease) of calcareous tooth" OR "ankylosis (disease) of the calcareous tooth" OR "ankylosis of tooth" OR "ankylosis of the tooth" OR "calcareous tooth ankylosis (disease)"

Run this search on Europe PMC

ClinicalTrials.gov query (quoted phrases + MeSH via query.cond, plus recall-expansion terms when used):

"Dental ankylosis" OR "Ankylosis of teeth" OR "Ankylosis of the teeth" OR "ankylosis (disease) of calcareous tooth" OR "ankylosis (disease) of the calcareous tooth" OR "ankylosis of tooth" OR "ankylosis of the tooth" OR "calcareous tooth ankylosis (disease)"

Interventional trials matched via: phrase (mesh = registered under a MeSH descriptor no name phrase would catch; recall-expansion = gene / selected parent terms used only for trials).

Study-type breakdown: 1 interventional · 0 observational · 0 expanded access. Only interventional studies enter the trial headline.

Parent-category trials query:

"ankylosis"

Query health: ok — strategies attempted: phrase; with hits: phrase

Run this search on ClinicalTrials.gov

Confidence reasoning

  • Preferred label is multi-word and distinctive
  • No synonyms dropped by stoplist
  • No label/synonym collisions with other diseases in this corpus

Ingested 2026-07-26T16:21:23.935Z